The pharmacoresistant epilepsy: an overview on existant and new emerging therapies

A Fattorusso, S Matricardi, E Mencaroni… - Frontiers in …, 2021 - frontiersin.org
Epilepsy is one of the most common neurological chronic disorders, with an estimated
prevalence of 0. 5–1%. Currently, treatment options for epilepsy are predominantly based on …

Infections, inflammation and epilepsy

A Vezzani, RS Fujinami, HS White, PM Preux… - Acta …, 2016 - Springer
Epilepsy is the tendency to have unprovoked epileptic seizures. Anything causing structural
or functional derangement of brain physiology may lead to seizures, and different conditions …

Imaging robust microglial activation after lipopolysaccharide administration in humans with PET

CM Sandiego, JD Gallezot, B Pittman… - Proceedings of the …, 2015 - National Acad Sciences
Neuroinflammation is associated with a broad spectrum of neurodegenerative and
psychiatric diseases. The core process in neuroinflammation is activation of microglia, the …

Autoimmune seizures and epilepsy

C Geis, J Planagumà, M Carreño… - The Journal of …, 2019 - Am Soc Clin Investig
The rapid expansion in the number of encephalitis disorders associated with autoantibodies
against neuronal proteins has led to an incremental increase in use of the term “autoimmune …

Dealing with danger in the CNS: the response of the immune system to injury

SP Gadani, JT Walsh, JR Lukens, J Kipnis - Neuron, 2015 - cell.com
Fighting pathogens and maintaining tissue homeostasis are prerequisites for survival. Both
of these functions are upheld by the immune system, though the latter is often overlooked in …

Neuroinflammatory mediators in acquired epilepsy: an update

Y Chen, MM Nagib, N Yasmen, MN Sluter… - Inflammation …, 2023 - Springer
Epilepsy is a group of chronic neurological disorders that have diverse etiologies but are
commonly characterized by spontaneous seizures and behavioral comorbidities. Although …

Pesticides at brain borders: Impact on the blood-brain barrier, neuroinflammation, and neurological risk trajectories

N Cresto, I Forner-Piquer, A Baig, M Chatterjee… - Chemosphere, 2023 - Elsevier
Pesticides are omnipresent, and they pose significant environmental and health risks.
Translational studies indicate that acute exposure to high pesticide levels is detrimental, and …

Advances and challenges in understanding cerebral toxoplasmosis

D Schlüter, A Barragan - Frontiers in immunology, 2019 - frontiersin.org
Toxoplasma gondii is a widespread parasitic pathogen that infects over one third of the
global human population. The parasite invades and chronically persists in the central …

Anti-inflammatory small molecules to treat seizures and epilepsy: from bench to bedside

A Dey, X Kang, J Qiu, Y Du, J Jiang - Trends in pharmacological sciences, 2016 - cell.com
As a crucial component of brain innate immunity, neuroinflammation initially contributes to
neuronal tissue repair and maintenance. However, chronic inflammatory processes within …

Albumin induces excitatory synaptogenesis through astrocytic TGF-β/ALK5 signaling in a model of acquired epilepsy following blood–brain barrier dysfunction

I Weissberg, L Wood, L Kamintsky, O Vazquez… - Neurobiology of …, 2015 - Elsevier
Post-injury epilepsy (PIE) is a common complication following brain insults, including
ischemic, and traumatic brain injuries. At present, there are no means to identify the patients …