The mammary gland is a highly dynamic organ that undergoes profound changes within its
epithelium during puberty and the reproductive cycle. These changes are fueled by …

Breast cancer prevention is daunting, yet not an unsurmountable goal. Mammary stem and
progenitors have been proposed as the cells‐of‐origin in breast cancer. Here, we present …

In BCR-ABL1 lymphoblastic leukemia, treatment heterogeneity to tyrosine kinase inhibitors
(TKIs), especially in the absence of kinase domain mutations in BCR-ABL1, is poorly …

Mammary tumor organoids have become a promising in vitro model for drug screening and
personalized medicine. However, the dependency on the basement membrane extract …

Glioblastoma (GBM) is characterized by extensive cellular and genetic heterogeneity. Its
initial presentation as primary disease (pGBM) has been subject to exhaustive molecular …

Cancer metabolism adapts the metabolic network of its tissue of origin. However, breast
cancer is not a disease of a single origin. Multiple epithelial populations serve as the culprit …

The mammary gland experiences substantial remodeling and regeneration during
development and reproductive life, facilitated by stem cells and progenitors that act in …

It is widely assumed that all normal somatic cells can equally perform homologous
recombination (HR) and non-homologous end joining in the DNA damage response (DDR) …

Human pluripotent stem cell differentiation towards hematopoietic progenitor cell can serve
as an in vitro model for human embryonic hematopoiesis, but the dynamic change of …

Breast cancer is a heterogenous disease that can be classified into multiple subtypes
including the most aggressive basal-like and triple-negative subtypes. Understanding the …