Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from
aerobic metabolism, as a result of accidental electron leakage as well as regulated …

Neurodegenerative diseases (NDs) are a wide class of disorders of the central nervous
system (CNS) with unknown etiology. Several factors were hypothesized to be involved in …

Type I Interferons (IFNs) induce the expression of> 500 genes, which are collectively called
ISGs (IFN-stimulated genes). One of the earliest ISGs induced by IFNs is ISG15 (Interferon …

Over the past 20 years, there has been a drastically increased understanding of the genetic
basis of Amyotrophic Lateral Sclerosis. Despite the identification of more than 40 different …

This review attempts to reconcile the present dual view of the mechanisms operating in
Amyotrophic Lateral Sclerosis (ALS). On one side, oxidative stress, mitochondrial damage …

Mounting evidence indicates that the lysosome-autophagy pathway plays a critical role in
iron release from ferritin, the main iron storage cellular protein, hence in the distribution of …

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two
neurodegenerative diseases in which similar pathogenic mechanisms are involved. Both …

Neurodegenerative diseases (NDs) are often associated with the presence of misfolded
protein inclusions. The chaperone HSPB8 is upregulated in mice, the human brain and …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that primarily
affects motoneurons, while non-neuronal cells may contribute to disease onset and …

Motoneuron diseases, like spinal bulbar muscular atrophy (SBMA) and amyotrophic lateral
sclerosis (ALS), are associated with proteins that because of gene mutation or peculiar …