Epithelial K+ channels are essential for maintaining electrolyte and fluid homeostasis in the
kidney. It is recognized that basolateral inward‐rectifying K+ (Kir) channels play an important …

Aldosterone excess is a pathogenic factor in many hypertensive disorders. The discovery of
numerous somatic and germline mutations in ion channels in primary hyperaldosteronism …

Background Patients with cystic fibrosis (CF) do not respond with increased urinary HCO 3−
excretion after stimulation with secretin and often present with metabolic alkalosis. Methods …

Potassium (K+) secretion by kidney tubule cells is central to electrolyte homeostasis in
mammals. In the K+-secreting principal cells of the distal nephron, electrogenic Na+ …

Background Increasing evidence implicates the signaling kinase mTOR complex-2
(mTORC2) in rapid renal responses to changes in plasma potassium concentration [K+] …

Aim Cystic fibrosis patients have an increased risk of developing metabolic alkalosis
presumably as a result of altered renal HCO3− handling. In this study, we directly assess the …

BACKGROUND: Increasing evidence implicates the signaling kinase mTOR complex-2
(mTORC2) in rapid renal responses to changes in plasma potassium concentration [K+] …

Aim High dietary K+ intake is associated with protection against hypertension. In mammals,
acute K+ intake induces natriuresis and kaliuresis, associated with a marked …

Background The secretin receptor (SCTR) is functionally expressed in the basolateral
membrane of the β-intercalated cells of the kidney cortical collecting duct and stimulates …

K+ balance in mammals relies on regulated renal K+ excretion matching unregulated
fluctuating K+ intake. Upon a K+ rich meal, rapid and powerful K+ excretion is needed …