Toward the Integration of Machine Learning and Molecular Modeling for Designing Drug Delivery Nanocarriers

XJ Gao, K Ciura, Y Ma, A Mikolajczyk… - Advanced …, 2024 - Wiley Online Library
The pioneering work on liposomes in the 1960s and subsequent research in controlled drug
release systems significantly advances the development of nanocarriers (NCs) for drug …

[HTML][HTML] Liposomes: Bridging the gap from lab to pharmaceuticals

R Eugster, P Luciani - Current Opinion in Colloid & Interface Science, 2024 - Elsevier
Liposomes are versatile and effective drug delivery systems, as highlighted by various
medical applications. Their well-defined bilayer structure is suited for the encapsulation of …

[HTML][HTML] Leveraging machine learning to streamline the development of liposomal drug delivery systems

R Eugster, M Orsi, G Buttitta, N Serafini, M Tiboni… - Journal of Controlled …, 2024 - Elsevier
Drug delivery systems efficiently and safely administer therapeutic agents to specific body
sites. Liposomes, spherical vesicles made of phospholipid bilayers, have become a …

Exploiting Pharma 4.0 Technologies in the Non-Biological Complex Drugs Manufacturing: Innovations and Implications

V Malheiro, J Duarte, F Veiga, F Mascarenhas-Melo - Pharmaceutics, 2023 - mdpi.com
The pharmaceutical industry has entered an era of transformation with the emergence of
Pharma 4.0, which leverages cutting-edge technologies in manufacturing processes. These …

A Coarse-Grained Molecular Dynamics Perspective on the Release of 5-Fluorouracil from Liposomes

RM Amărandi, L Marin, B Drăgoi… - Molecular …, 2024 - ACS Publications
Liposomes, small bilayer phospholipid-containing vesicles, are frequently used to ensure
slow drug release for a prolonged and improved therapeutic effect. Nevertheless, current …

Artificial intelligence-driven hydrogel microneedle patches integrating 5-fluorouracil inclusion complex-loaded flexible pegylated liposomes for enhanced non …

P Suriyaamporn, C Pornpitchanarong… - International Journal of …, 2024 - Elsevier
The current study focused on the development of crosslinked hydrogel microneedle patches
(cHMNs) incorporating 5-FU-hydroxypropyl beta-cyclodextrin inclusion complex-loaded …

Enhancing the Encapsulation Performances of Liposomes for Amphiphilic Copolymers by Computer Simulations

B Chen, Q Xia, J Li, G Cai, Q Wang - The Journal of Physical …, 2024 - ACS Publications
Liposomes, which encapsulate drugs into an inner aqueous core and demonstrate high
drug-loading capacity, have attracted considerable interest in the field of drug delivery …

Machine learning-assisted rheumatoid arthritis formulations: a review on smart pharmaceutical design

N Pouyanfar, Z Anvari, K Davarikia, P Aftabi… - Materials Today …, 2024 - Elsevier
Rheumatoid arthritis (RA) is a long-lasting autoimmune condition that causes significant
suffering among those affected. The medications used to treat this disease, including …

Construction of degradable liposome-templated microporous metal-organic frameworks with commodious space for enzymes

C Cheng, N Ali, J Liu, J Qiao, M Wang, L Qi - Chinese Chemical Letters, 2024 - Elsevier
The construction of enzyme reactors based on metal-organic frameworks (MOFs) as the
immobilized matrix is a proven strategy that has achieved the widespread application of …

Evaluation and Prediction of Encapsulation of Bioactives in Cell-Based Microcarriers Using Machine Learning Approaches

Y Lu, C Kusnadi, N Nitin - Food and Bioprocess Technology, 2024 - Springer
Cell-based encapsulation systems can improve the stability and delivery of diverse
bioactives, but predicting encapsulation efficiency is challenging due to various intrinsic and …