The benefits of exercise on health and longevity are well-established, and evidence
suggests that these effects are partially driven by a spectrum of bioactive molecules …

During the past decade, skeletal muscle has been identified as a secretory organ.
Accordingly, we have suggested that cytokines and other peptides that are produced …

The concept of a “polypill” is receiving growing attention to prevent cardiovascular disease.
Yet similar if not overall higher benefits are achievable with regular exercise, a drug-free …

Persistent systemic inflammation, a typical feature of inflammatory rheumatic diseases, is
associated with a high cardiovascular risk and predisposes to metabolic disorders and …

Exercise has beneficial effects in ameliorating metabolic disorders, and a combined
therapeutic regimen of regular exercise and pharmaceutical treatment is often …

Sarcopenia is a geriatric syndrome characterized by the progressive degeneration of muscle
mass and function, and it is associated with severe complications, which are falls, functional …

Type 2 diabetes mellitus (T2DM) is associated with metabolic dysregulation and chronic
inflammation, and regular exercise may provide a strong stimulus for improving both. In this …

Exercise reduces the risk of a multitude of disorders, from metabolic disease to cancer, but
the molecular mechanisms mediating the protective effects of exercise are not completely …

Skeletal muscle is the largest organ in the body. Skeletal muscles are primarily
characterized by their mechanical activity required for posture, movement, and breathing …

This review summarizes the current literature regarding the most discussed contraction‐
regulated moykines like IL‐6, IL‐15, irisin, BDNF, ANGPTL4, FGF21, myonectin and MCP‐1 …