The occurrence of modified bases in DNA is attributed to some major factors: incorporation
of altered nucleotide building blocks and chemical reactions or radiation effects on bases …

Deciphering the molecular mechanisms that control relevant cellular processes is of utmost
importance to understand how viruses, prokaryotic and eukaryotic cells work. The diversity …

Arginine finger is a highly conserved and essential residue in many GTPase and AAA+
ATPase enzymes that completes the active site from a distinct protomer, forming contacts …

Thymidine biosynthesis is essential in all cells. Inhibitors of the enzymes involved in this
pathway (eg methotrexate) are thus frequently used as cytostatics. Due to its pivotal role in …

Transfer of phage-related pathogenicity islands of Staphylococcus aureus (SaPI-s) was
recently reported to be activated by helper phage dUTPases. This is a novel function for …

Summary dUTPases (Duts) have emerged as promising regulatory molecules controlling
relevant cellular processes. However, the mechanism underlying this regulatory function …

Cisplatin resistance hinders the improvement of the prognosis of patients with ovarian
cancer. Cisplatin induces cancer cell apoptosis by inducing reactive oxygen species (ROS) …

Phosphorylation adjacent to nuclear localization signals (NLSs) is involved in the regulation
of nucleocytoplasmic transport. The nuclear isoform of human dUTPase, an enzyme that is …

The human gastric pathogen Helicobacter pylori chronically affects the gastric mucosal layer
of approximately half of world's population. The emergence of resistant strains urges the …

Most enzymes present a catalytic mechanism where one or more proton transfer events
occur coupled tightly together with the enzymatic chemical reaction. We show here that …