H1 histones: current perspectives and challenges
H1 and related linker histones are important both for maintenance of higher-order chromatin
structure and for the regulation of gene expression. The biology of the linker histones is …
structure and for the regulation of gene expression. The biology of the linker histones is …
Unraveling linker histone interactions in nucleosomes
Considerable progress has been made recently in defining the interactions of linker histones
(H1s) within nucleosomes. Major advancements include atomic resolution structures of the …
(H1s) within nucleosomes. Major advancements include atomic resolution structures of the …
Mapping of six somatic linker histone H1 variants in human breast cancer cells uncovers specific features of H1. 2
L Millan-Arino, AB Islam… - Nucleic acids …, 2014 - academic.oup.com
Seven linker histone H1 variants are present in human somatic cells with distinct prevalence
across cell types. Despite being key structural components of chromatin, it is not known …
across cell types. Despite being key structural components of chromatin, it is not known …
Conformational selection and dynamic adaptation upon linker histone binding to the nucleosome
Linker histones are essential for DNA compaction in chromatin. They bind to nucleosomes in
a 1: 1 ratio forming chromatosomes. Alternative configurations have been proposed in which …
a 1: 1 ratio forming chromatosomes. Alternative configurations have been proposed in which …
Binding dynamics of disordered linker histone H1 with a nucleosomal particle
Linker histone H1 is an essential regulatory protein for many critical biological processes,
such as eukaryotic chromatin packaging and gene expression. Mis-regulation of H1s is …
such as eukaryotic chromatin packaging and gene expression. Mis-regulation of H1s is …
Interplay between histone H1 structure and function
A Roque, I Ponte, P Suau - Biochimica et Biophysica Acta (BBA)-Gene …, 2016 - Elsevier
H1 linker histones are involved both in the maintenance of higher-order chromatin structure
and in gene regulation. Histone H1 exists in multiple isoforms, is evolutionarily variable and …
and in gene regulation. Histone H1 exists in multiple isoforms, is evolutionarily variable and …
Protein disorder-to-order transition enhances the nucleosome-binding affinity of H1
A Sridhar, M Orozco… - Nucleic acids …, 2020 - academic.oup.com
Intrinsically disordered proteins are crucial elements of chromatin heterogenous
organization. While disorder in the histone tails enables a large variation of inter …
organization. While disorder in the histone tails enables a large variation of inter …
Sperm-specific histone H1 in highly condensed sperm nucleus of Sargassum horneri
Y Takeuchi, S Sato, C Nagasato, T Motomura… - Scientific Reports, 2024 - nature.com
Spermatogenesis is one of the most dramatic changes in cell differentiation. Remarkable
chromatin condensation of the nucleus is observed in animal, plant, and algal sperm. Sperm …
chromatin condensation of the nucleus is observed in animal, plant, and algal sperm. Sperm …
Post-translational modifications of the intrinsically disordered terminal domains of histone H1: effects on secondary structure and chromatin dynamics
A Roque, I Ponte, P Suau - Chromosoma, 2017 - Springer
H1 linker histones are involved both in the maintenance of chromatin higher-order structure
and in gene regulation. H1 binds to linker DNA regions on the surface of the nucleosome. In …
and in gene regulation. H1 binds to linker DNA regions on the surface of the nucleosome. In …
Modulation of chromatin function through linker histone H1 variants
A Kowalski, J Pałyga - Biology of the Cell, 2016 - Wiley Online Library
In this review, the structural aspects of linker H1 histones are presented as a background for
characterization of the factors influencing their function in animal and human chromatin. The …
characterization of the factors influencing their function in animal and human chromatin. The …