NM Moussa‐Pacha, SM Abdin, HA Omar… - Medicinal research …, 2020 - Wiley Online Library
Alzheimer's disease (AD) is an irreversible, progressive neurodegenerative brain disorder with no current cure. One of the important therapeutic approaches of AD is the inhibition of β …
EM Foster, A Dangla-Valls, S Lovestone… - Frontiers in …, 2019 - frontiersin.org
Clusterin (CLU) or APOJ is a multifunctional glycoprotein that has been implicated in several physiological and pathological states, including Alzheimer's disease (AD). With a prominent …
We review the genetic risk factors for late-onset Alzheimer's disease (AD) and their role in AD pathogenesis. More recent advances in understanding of the human genome …
L Zuroff, D Daley, KL Black… - Cellular and Molecular …, 2017 - Springer
Deficiency in cerebral amyloid β-protein (Aβ) clearance is implicated in the pathogenesis of the common late-onset forms of Alzheimer's disease (AD). Accumulation of misfolded Aβ in …
D Harold, R Abraham, P Hollingworth, R Sims… - Nature …, 2009 - nature.com
We undertook a two-stage genome-wide association study (GWAS) of Alzheimer's disease (AD) involving over 16,000 individuals, the most powerful AD GWAS to date. In stage 1 …
The gene encoding apolipoprotein E (APOE) on chromosome 19 is the only confirmed susceptibility locus for late-onset Alzheimer's disease. To identify other risk loci, we …
DA Butterfield, AM Swomley… - Antioxidants & redox …, 2013 - liebertpub.com
Significance: Alzheimer disease (AD) is an age-related neurodegenerative disease. AD is characterized by progressive cognitive impairment. One of the main histopathological …
F Cioffi, RHI Adam, K Broersen - Journal of Alzheimer's …, 2019 - content.iospress.com
Alzheimer's disease is the most common neurodegenerative disorder that can cause dementia in elderly over 60 years of age. One of the disease hallmarks is oxidative stress …
MP Lambert, AK Barlow, BA Chromy… - Proceedings of the …, 1998 - National Acad Sciences
Aβ1–42 is a self-associating peptide whose neurotoxic derivatives are thought to play a role in Alzheimer's pathogenesis. Neurotoxicity of amyloid β protein (Aβ) has been attributed to …