Lipid phosphoinositides are master regulators of almost all aspects of a cell's life and death
and are generated by the tightly regulated activity of phosphoinositide kinases. Although …

Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Virus entry is a multistep process. It initiates when the virus attaches to the host cell and
ends when the viral contents reach the cytosol. Genetically unrelated viruses can subvert …

Infections by the Ebola and Marburg filoviruses cause a rapidly fatal haemorrhagic fever in
humans for which no approved antivirals are available. Filovirus entry is mediated by the …

Lysosomes are key cellular catabolic centers that also perform fundamental metabolic,
signaling and quality control functions. Lysosomes are not static and they respond …

Endocytosis, phagocytosis, and macropinocytosis are fundamental processes that enable
cells to sample their environment, eliminate pathogens and apoptotic bodies, and regulate …

Phosphoinositide signaling lipids (PIPs) are key regulators of membrane identity and
trafficking. Of these, PI (3, 5) P2 is one of the least well-understood, despite key roles in …

Phosphoinositides are lipids that are present in the cytoplasmic leaflet of a cell's plasma and
internal membranes and play pivotal roles in the regulation of a wide variety of cellular …

Toll-like receptor (TLR) signaling is a key component of innate immunity. Aberrant TLR
activation leads to immune disorders via dysregulation of cytokine production, such as IL …

Recent studies of the low abundant signaling lipid, phosphatidylinositol 3, 5‐bisphosphate
(PI (3, 5) P2), reveal an intriguingly diverse list of downstream pathways, the intertwined …