ATPases associated with diverse cellular activities (AAA+ proteins) are macromolecular
machines that convert the chemical energy contained in ATP molecules into powerful …

Peroxisomes are key metabolic organelles, which contribute to cellular lipid metabolism, eg
the β-oxidation of fatty acids and the synthesis of myelin sheath lipids, as well as cellular …

Peroxisomes are ubiquitous organelles that house various metabolic reactions and are
essential for human health,,–. Luminal peroxisomal proteins are imported from the cytosol by …

Peroxisomes are rapidly degraded during amino acid and oxygen deprivation by a type of
selective autophagy called pexophagy. However, how damaged peroxisomes are detected …

Abstract Significance: p62/SQSTM1 is a multifunctional scaffolding protein involved in the
regulation of various signaling pathways as well as autophagy. In particular, p62/SQSTM1 …

Peroxisomes are vital metabolic organelles that import their lumenal (matrix) enzymes from
the cytosol using mobile receptors. Surprisingly, the receptors can even import folded …

Blobel and coworkers discovered in 1978 that peroxisomal proteins are synthesized on free
ribosomes in the cytosol and thus provided the grounds for the conception of peroxisomes …

Peroxisomes are organelles that play a central role in lipid metabolism and cellular redox
homeostasis. The import of peroxisomal matrix proteins by peroxisomal targeting signal …

In the N-degron pathway, N-recognins recognize cognate substrates for degradation via the
ubiquitin (Ub)-proteasome system (UPS) or the autophagy-lysosome system (hereafter …

The AAA protein Msp1 extracts mislocalized tail-anchored membrane proteins and targets
them for degradation, thus maintaining proper cell organization. How Msp1 selects its …