Mitochondria play a central role in cell biology not only as producers of ATP, but also in the
sequestration of Ca2+ and the generation of free radicals. They are also repositories of …

It is assumed that the survival factors Bcl-2 and Bcl-xL are mainly functional on mitochondria
and therefore must contain mitochondrial targeting sequences. Here we show, however, that …

Staurosporine has long been used in vitro as an initiator of apoptosis in many different cell
types, but the mechanism involved remains poorly understood. In the present study, we have …

Preventing massive cell death is an important therapeutic strategy for various injuries and
disorders. Protein therapeutics have the advantage of delivering proteins in a short period …

The potential toxic effects of high extracellular concentrations of fatty acids were tested in β
(INS-1)-cells cultured in the absence of serum, a condition known to alter cell survival in …

Oxidative stress and apoptosis play pivotal roles in the pathogenesis of neurodegenerative
diseases. We investigated the effects of vitamin E analogs on oxidative stress and apoptosis …

Issues associated with upscaling exosome production for therapeutic use may be overcome
through utilizing artificial exosomes. Cell‐derived mimetic nanovesicles (M‐NVs) are a …

The efficacy of fluorescence-guided surgery in facilitating the real-time delineation of
tumours depends on the optical contrast of tumour tissue over healthy tissue. Here we show …

DJ‐1 is a conserved protein reported to be involved in diverse cellular processes ranging
from cellular transformation, control of protein–RNA interaction, oxidative stress response to …

The hematopoietic cytokine erythropoietin (Epo) exerts cytoprotective effects on several
types of neuronal cells both in vivo and in culture. Detailed molecular mechanisms …