Glycobiology is the comprehensive biological investigation of carbohydrates. The study of
the role and function of complex carbohydrates often requires the attachment of …

Peptides are an important class of molecules with diverse biological activities. Many
endogenous peptides, especially neuropeptides and peptide hormones, play critical roles in …

Background Brain capillary endothelial cells (BCECs) experience hypoxic conditions during
early brain development. The newly formed capillaries are tight and functional before …

Despite various advantages, opioid peptides have been limited in their therapeutic uses due
to the main drawbacks in metabolic stability, blood-brain barrier permeability, and …

Still nowadays pain is one of the most common disabling conditions and yet it remains too
often unsolved. Analgesic opioid drugs, and mainly MOR agonists such as morphine, are …

Glycopeptides related to β-endorphin penetrate the blood–brain barrier (BBB) of mice to
produce antinociception. Two series of glycopeptides were assessed for opioid receptor …

We describe the design and synthesis of novel bivalent ligands based on the conjugation of
4-anilidopiperidine derivatives with enkephalin analogues. The design of non-peptide …

Three N‐Boc‐protected amino acids, l‐serine, l‐aspartic, and l‐glutamic acid, were either
converted into their methyl azidoalkanoates or various alkynes via Bestmann‐Ohira strategy …

The production of analytical amounts of azido sugars is used as a means of verifying
catalytic acid/base mutations of retaining glycosidase, but application of this process to …

A general procedure for the rapid diversification of peptide scaffolds is described. A one-pot
click reaction between a peptide-alkyne and a series of in situ generated aryl/alkyl azides …