The morbidity and mortality of HIV type-1 (HIV-1)-related diseases were dramatically
diminished by the grounds of the introduction of potent antiretroviral therapy, which induces …

Methods A comprehensive review of the English‐language publications was implemented.
We searched PubMed, JSTOR and Scopus electronic databases with keyword combinations …

Individuals infected with human immunodeficiency virus type-1 (HIV-1) show metabolic
alterations of CD4+ T cells through unclear mechanisms with undefined consequences. We …

Systemic immune activation has emerged as an essential component of the
immunopathogenesis of HIV. It not only leads to faster disease progression, but also to …

For more than two decades, CD4 cell count measurements have been central to
understanding HIV disease progression, making important clinical decisions, and monitoring …

Haematological and immunological abnormalities abound in HIV infections. Reduced CD4+
T cells, changes in cytokine profiles, and impaired immunity are the key immunological …

The T helper 17 (Th17) cells represent a subset of CD4+ T-cells with unique effector
functions, developmental plasticity, and stem-cell features. Th17 cells bridge innate and …

Abstract Background People with HIV (PWH) are at increased risk of severe COVID‐19. We
aimed to determine humoral responses in PWH and controls who received two doses of …

Decades of studies in antiretroviral therapy (ART) have passed, and the mechanisms that
determine impaired immunological recovery in HIV-positive patients receiving ART have not …

The aim was to analyze clinical complications in HIV-infected subjects who persistently
maintain low CD4 levels despite virological response to cART in the Spanish CoRIS cohort …