Apoptosis is a major form of cell death, characterized initially by a series of stereotypic
morphological changes. In the nematode Caenorhabditis elegans, the gene ced-3 encodes …

▪ Abstract Apoptosis is a genetically programmed, morphologically distinct form of cell death
that can be triggered by a variety of physiological and pathological stimuli. Studies …

Bcl-2 is an integral membrane protein located mainly on the outer membrane of
mitochondria. Overexpression of Bcl-2 prevents cells from undergoing apoptosis in …

In a cell-free apoptosis system, mitochondria spontaneously released cytochrome c, which
activated DEVD-specific caspases, leading to fodrin cleavage and apoptotic nuclear …

We report here the purification and cDNA cloning of Apaf-1, a novel 130 kd protein from
HeLa cell cytosol that participates in the cytochrome c–dependent activation of caspase-3 …

We have identified two cell types, each using almost exclusively one of two different CD95
(APO‐1/Fas) signaling pathways. In type I cells, caspase‐8 was activated within seconds …

▪ Abstract An expanding family of BCL-2 related proteins share homology, clustered within
four conserved regions, namely BCL-2 homology (BH1-4) domains, which control the ability …

▪ Abstract Apoptosis, a physiological process for killing cells, is critical for the normal
development and function of multicellular organisms. Abnormalities in cell death control can …

Extracellular survival factors alter a cell's susceptibility to apoptosis, often through
posttranslational mechanisms. However, no consistent relationship has been established …

To identify CAP3 and CAP4, components of the CD95 (Fas/APO-1) death-inducing signaling
complex, we utilized nano-electrospray tandem mass spectrometry, a recently developed …