Molecular targeted therapies are revolutionized therapeutics which interfere with specific
molecules to block cancer growth, progression, and metastasis. Many molecular targeted …

Molecular targeted therapy plays an increasingly important role in the treatment of metastatic
pheochromocytomas and paragangliomas (PPGLs), which are rare tumors but remain …

Background Amplification of the epidermal growth factor receptor (EGFR) and its mutant
EGFRvIII are among the most common genetic alterations in glioblastoma (GBM), the most …

To date, five cancer treatment modalities have been defined. The three traditional modalities
of cancer treatment are surgery, radiotherapy, and conventional chemotherapy, and the two …

Chemoresistance is a major obstacle that limits the benefits of cisplatin-based
chemotherapy in various cancers, including hepatocellular carcinoma. De-regulation of the …

Nifuroxazide (NFX) is a safe nitrofuran antibacterial drug used clinically to treat acute
diarrhea and infectious traveler diarrhea or colitis. Recent studies revealed that NFX …

Abnormally alternative splicing events are common hallmark of diverse types of cancers.
Splicing variants with aberrant functions play an important role in cancer development. Most …

Talazoparib (Talzenna) is a novel poly (adenosine diphosphate-ribose) polymerase (PARP)
inhibitor that is clinically used for the therapy of breast cancer. Furthermore, the drug has …

Methotrexate (MTX) is used extensively in cancer chemotherapy and for the management of
various autoimmune disorders such as rheumatoid arthritis and psoriasis. The well reported …

A series of novel N‐aryl‐5‐aryl‐6, 7, 8, 9‐tetrahydropyrimido [4, 5‐b] quinolin‐4‐amines 4a–
4l was synthesized as potential anticancer agents through Dimroth rearrangement reaction …