Molecular dynamics (MD) simulations have become increasingly useful in the modern drug
development process. In this review, we give a broad overview of the current application …

Recognition of the natural abundance and functional importance of intrinsically disordered
proteins (IDPs), and protein hybrids that contain both intrinsically disordered protein regions …

Many proteins and protein segments cannot attain a single stable three-dimensional
structure under physiological conditions; instead, they adopt multiple interconverting …

In eukaryotic cells, diverse stresses trigger coalescence of RNA-binding proteins into stress
granules. In vitro, stress-granule-associated proteins can demix to form liquids, hydrogels …

Phase separation of intrinsically disordered proteins (IDPs) is a remarkable feature of living
cells to dynamically control intracellular partitioning. Despite the numerous new IDPs that …

Intrinsically disordered proteins (IDPs) are important components of the cellular signalling
machinery, allowing the same polypeptide to undertake different interactions with different …

Over the past decade, we have observed a massive increase in the amount of information
describing protein sequences from a variety of organisms. 1, 2 While this may reflect the …

We introduce a new representation and feature extraction method for biological sequences.
Named bio-vectors (BioVec) to refer to biological sequences in general with protein-vectors …

Motivation: A sizeable fraction of eukaryotic proteins contain intrinsically disordered regions
(IDRs), which act in unfolded states or by undergoing transitions between structured and …

Intrinsically disordered proteins and regions (IDPs) represent a large class of proteins that
are defined by conformational heterogeneity and lack of persistent tertiary/secondary …