Investigations of apolipoprotein E (APOE) gene, the major genetic risk modifier for
Alzheimer's disease (AD), have yielded significant insights into the pathogenic mechanism …

Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in
adults over 50 years old. Genetic, epidemiological, and molecular studies are beginning to …

Summary The apolipoprotein E4 (APOE4) allele is associated with an increased risk of
Alzheimer disease and a decreased risk of glaucoma, but the underlying mechanisms …

Microglia from different nervous system regions are molecularly and anatomically distinct,
but whether they also have different functions is unknown. We combined lineage tracing …

Genome-wide association studies have identified many variants that each affects multiple
traits, particularly across autoimmune diseases, cancers and neuropsychiatric disorders …

A biomarker can be a substance or structure measured in body parts, fluids or products that
can affect or predict disease incidence. As age-related macular degeneration (AMD) is the …

Age-related macular degeneration (AMD) is a common cause of blindness in older
individuals. To accelerate the understanding of AMD biology and help design new …

Corneal transplantation or keratoplasty has developed rapidly in the past 10 years.
Penetrating keratoplasty, a procedure consisting of full-thickness replacement of the cornea …

As the age of the population increases in many nations, age‐related degenerative diseases
pose significant socioeconomic challenges. One of the key degenerative diseases that …

Age-related macular degeneration is a major cause of blindness worldwide. With ageing
populations in many countries, more than 20% might have the disorder. Advanced age …