Brain metastases cause significant morbidity and mortality in patients with advanced cancer.
In the era of precision oncology and immunotherapy, there are rapidly evolving systemic …

Background Patients with inflammatory bowel diseases (IBD) sometimes require
investigational medicinal therapy in a clinical trial. Before enrollment, patients must meet …

PURPOSE Early discontinuation affects more than one third of patients enrolled in early-
phase oncology clinical trials. Early discontinuation is deleterious both for the patient and for …

Background Access to clinical trials and especially early-phase trials (ECT) is an important
issue in geriatric oncology. As cancer can be considered an age-related disease because …

Background Early-phase clinical trials (EPCT) represent an important part of innovations in
medical oncology and a valuable therapeutic option for patients with metastatic cancers …

Background Selecting patients for early clinical trials is a challenging process and clinicians
lack sufficient tools to predict overall survival (OS). Circulating cell-free DNA (cfDNA) has …

PURPOSE To compare the computability of Observational Medical Outcomes Partnership
(OMOP)–based queries related to prescreening of patients using two versions of the OMOP …

PURPOSE: Patients with advanced cancer and oncologists deliberate about early-phase
(EP) trials as they consider whether to pursue EP trial enrollment. We have limited …

Multiple factors critical to the effectiveness of academic phase I cancer programs were
assessed among 16 academic centers in the US Successful cancer centers were defined as …

Le cancer est un enjeu de santé publique dont l'amélioration de la prise en charge repose,
entre autres leviers, sur l'exploitation d'entrepôts de données de santé (EDS). Leur …