The transactivation domain of the cAMP response element-binding protein (CREB) consists
of two major domains. The glutamine-rich Q2 domain, which interacts with the general …

Numerous cellular processes require the concerted action of multiple proteins that assemble
in functional complexes. Protein-protein interaction domains allow specific proteins to …

The sphingolipid ceramide negatively regulates insulin action by inhibiting Akt/protein
kinase B (PKB), a serine/threonine kinase that is a central regulator of glucose uptake and …

Background & Aims: FHL2 (4-1/2 LIM protein 2) is an adapter and modifier in protein
interactions that is expressed mainly in the heart and ovary. It functions in a cell type-or …

FHL2, a molecule that interacts with many integrins and transcription factors, was found to
play an important role in osteoblast differentiation. Overexpression of FHL2 increases the …

The neuropeptide pituitary adenylate cyclase‐activating polypeptide (PACAP) inhibits C2‐
ceramide‐induced cell death through blockade of the mitochondrial apoptotic pathway in rat …

Abstract Proline-, glutamic acid-, and leucine-rich protein-1 (PELP1) is a coregulator of
multiple nuclear receptors. Molecular mechanisms of PELP1 function are not completely …

Cell–extracellular matrix (ECM) adhesion is crucial for control of cell behavior. It connects
the ECM to the intracellular cytoskeleton and transduces bidirectional signals between the …

Although members of a virus family produce similar gene products, those products may have
quite different functions. Simian virus 40 (SV40) large T antigen (LT), for example, targets …

Cystic fibrosis (CF), a common lethal pulmonary disorder in Caucasians, is caused by
mutations in the cystic fibrosis transmembrane conductance regulator gene (CFTR) that …