Diversification of ubiquinone biosynthesis via gene duplications, transfers, losses, and parallel evolution

K Kazemzadeh, L Pelosi, C Chenal… - Molecular Biology …, 2023 - academic.oup.com
The availability of an ever-increasing diversity of prokaryotic genomes and metagenomes
represents a major opportunity to understand and decipher the mechanisms behind the …

Pyridoxal 5′-Phosphate Biosynthesis by Pyridox-(am)-ine 5′-Phosphate Oxidase: Species-Specific Features

M Rivero, N Novo, M Medina - International Journal of Molecular Sciences, 2024 - mdpi.com
Enzymes reliant on pyridoxal 5′-phosphate (PLP), the metabolically active form of vitamin
B6, hold significant importance in both biology and medicine. They facilitate various …

Multisubstrate specificity shaped the complex evolution of the aminotransferase family across the tree of life

K Koper, SW Han, R Kothadia… - Proceedings of the …, 2024 - National Acad Sciences
Aminotransferases (ATs) are an ancient enzyme family that play central roles in core
nitrogen metabolism, essential to all organisms. However, many of the AT enzyme functions …

[HTML][HTML] Protective effects of Abrus cantoniensis Hance against liver injury through modulation of intestinal microbiota and liver metabolites

C Xu, M Ali, J Sun, X Li, D Fouad, M Iqbal… - Ecotoxicology and …, 2024 - Elsevier
Abrus cantoniensis Hance (ACH) is an ancient Chinese medicine herb known for its
therapeutic effects. This study investigated the potential protective effect of ACH against …

Fine-Tuning Pyridoxal 5′-Phosphate Synthesis in Escherichia coli for Cadaverine Production in Minimal Culture Media

C Liu, C Gao, L Song, X Li, X Chen, J Wu… - ACS Synthetic …, 2024 - ACS Publications
Cadaverine is a critical C5 monomer for the production of polyamides. Pyridoxal 5′-
phosphate (PLP), as a crucial cofactor for the key enzyme lysine decarboxylase in the …