Targeting the transferrin receptor for brain drug delivery
Obtaining efficient drug delivery to the brain remains the biggest challenge for the
development of therapeutics to treat diseases of the central nervous system. The main …
development of therapeutics to treat diseases of the central nervous system. The main …
Cholinergic system during the progression of Alzheimer's disease: therapeutic implications
Alzheimer's disease (AD) is characterized by a progressive phenotypic downregulation of
markers within cholinergic basal forebrain (CBF) neurons, frank CBF cell loss and reduced …
markers within cholinergic basal forebrain (CBF) neurons, frank CBF cell loss and reduced …
The role of neuronal growth factors in neurodegenerative disorders of the human brain
B Connor, M Dragunow - Brain Research Reviews, 1998 - Elsevier
Recent evidence suggests that neurotrophic factors that promote the survival or
differentiation of developing neurons may also protect mature neurons from neuronal …
differentiation of developing neurons may also protect mature neurons from neuronal …
The role of nerve growth factor receptors in cholinergic basal forebrain degeneration in prodromal Alzheimer disease
Dysfunction of nerve growth factor (NGF) and its high (TrkA) and low (p75NTR) affinity
receptors has been suggested to underlie the selective degeneration of the nucleus basalis …
receptors has been suggested to underlie the selective degeneration of the nucleus basalis …
Loss of cholinergic phenotype in basal forebrain coincides with cognitive decline in a mouse model of Down's syndrome
ACE Granholm, LA Sanders, LS Crnic - Experimental neurology, 2000 - Elsevier
Mice with segmental trisomy of chromosome 16 (Ts65Dn) have been used as a model for
Down's syndrome. These mice are born with a normal density of basal forebrain cholinergic …
Down's syndrome. These mice are born with a normal density of basal forebrain cholinergic …
Expression of neurotrophins and their receptors in human bone marrow
E Labouyrie, P Dubus, A Groppi, FX Mahon… - The American journal of …, 1999 - Elsevier
The expression of neurotrophins and their receptors, the low-affinity nerve growth factor
receptor (p75LNGFR) and the Trk receptors (TrkA, TrkB, and TrkC), was investigated in …
receptor (p75LNGFR) and the Trk receptors (TrkA, TrkB, and TrkC), was investigated in …
Alzheimer's disease and Down's syndrome: roles of APP, trophic factors and ACh
O Isacson, H Seo, L Lin, D Albeck… - TRENDS in …, 2002 - cell.com
Recent therapeutic investigations of Alzheimer's disease (AD) have been guided by two
seemingly opposed hypotheses: the amyloid cascade theory, which favors the amyloid …
seemingly opposed hypotheses: the amyloid cascade theory, which favors the amyloid …
Nerve growth factor pathobiology during the progression of Alzheimer's disease
The current review summarizes the pathobiology of nerve growth factor (NGF) and its
cognate receptors during the progression of Alzheimer's disease (AD). Both transcript and …
cognate receptors during the progression of Alzheimer's disease (AD). Both transcript and …
Altered synaptic function in Alzheimer's disease
KFS Bell, AC Cuello - European journal of pharmacology, 2006 - Elsevier
Alzheimer's disease is the leading cause of dementia in the elderly, presenting itself
clinically by progressive loss of memory and learning. Since synaptic density correlates …
clinically by progressive loss of memory and learning. Since synaptic density correlates …
Developmental origins of the age-related decline in cortical cholinergic function and associated cognitive abilities
M Sarter, JP Bruno - Neurobiology of aging, 2004 - Elsevier
Ontogenetic abnormalities in the regulation of the cortical cholinergic input system are
hypothesized to mediate early-life cognitive limitations (ECL) that later escalate, based on …
hypothesized to mediate early-life cognitive limitations (ECL) that later escalate, based on …