The stimulator of interferon genes (STING) cellular signaling pathway is a promising target
for cancer immunotherapy. Activation of the intracellular STING protein triggers the …

Tumorigenesis is a complex and dynamic process, consisting of three stages: initiation,
progression, and metastasis. Tumors are encircled by extracellular matrix (ECM) and …

For many solid malignancies, lymph node (LN) involvement represents a harbinger of
distant metastatic disease and, therefore, an important prognostic factor. Beyond its utility as …

A significant fraction of the total immune cells in the body are located in several hundred
lymph nodes, in which lymphocyte accumulation, activation and proliferation are organized …

In contrast to solid cancers, which often require genetic modifications and complex cellular
reprogramming for effective metastatic dissemination, leukaemic cells uniquely possess the …

Lymph node metastases in cancer patients are associated with tumor aggressiveness,
poorer prognoses, and the recommendation for systemic therapy. Whether cancer cells in …

Simple Summary The tumor microenvironment (TME) in breast cancer plays important roles
in tumor behavior and treatment response, making its pathologic assessment critical for …

Metastasis has long been understood to lead to the overwhelming majority of cancer-related
deaths. However, our understanding of the metastatic process, and thus our ability to …

Immunomodulators that remodel the tumor immunosuppressive microenvironment have
been combined with anti–programmed death 1 (α-PD1) or anti–programmed death ligand 1 …

The tumor microenvironment plays a pivotal role in tumor initiation and progression by
creating a dynamic interaction with cancer cells. The tumor microenvironment consists of …