The endoplasmic reticulum is an organelle with multiple functions. The synthesis of
transmembrane proteins and proteins that are to be secreted occurs in this organelle. Many …

Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon,
inevitable in kidney transplantation and one of the most important mechanisms for non-or …

Autophagy as a means of cell killing was first advanced by Clark's phenotypic description of
'Type II autophagic cell death'in 1990. However, this phenomenon later came into question …

Autophagy is a conserved multistep pathway that degrades and recycles damaged
organelles and macromolecules to maintain intracellular homeostasis. The autophagy …

Autophagy and apoptosis are two important catabolic processes contributing to the
maintenance of cellular and tissue homeostasis. Autophagy controls the turnover of protein …

Not surprisingly, the death of a cell is a complex and well controlled process. For several
decades, apoptosis, the first genetically programmed death process to be identified has …

ABSTRACT TAR DNA-binding protein (TDP-43, also known as TARDBP) is the major
pathological protein in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia …

Apoptosis and autophagy are two evolutionarily conserved processes that maintain
homeostasis during stress. Although the two pathways utilize fundamentally distinct …

Autophagy and apoptosis are two evolutionarily conserved processes that regulate cell fate
in response to cytotoxic stress. However, the functional relationship between these two …

Caspases are a family of cysteine proteases widely known as the principal mediators of the
apoptotic cell death response, but considerably less so as the contributors to the regulation …