Since its discovery over 35 years ago, MDM2 has emerged as an attractive target for the
development of cancer therapy. MDM2's activities extend from carcinogenesis to immunity to …

The p53 tumor suppressor is a key transcription factor regulating cellular pathways such as
DNA repair, cell cycle, apoptosis, angiogenesis, and senescence. It acts as an important …

The p53 tumor suppressor is activated in response to cellular stresses to induce cell-cycle
arrest, cellular senescence, and apoptosis. The p53 gene is inactivated by mutations in …

It is now clear that functional p53 is critical to protect the genome from alterations that lead to
tumorigenesis. However, with the myriad of cellular stresses and pathways linked to p53 …

Ribosomal proteins (RPs), the essential components of the ribosome, are a family of RNA-
binding proteins, which play prime roles in ribosome biogenesis and protein translation …

Pancreatic adenocarcinoma is a malignancy with rising incidence and grim prognosis.
Despite improvements in therapeutics for treating metastatic pancreatic cancer, this disease …

The murine double minute 2 (MDM2) oncogene exerts major oncogenic activities in human
cancers; it is not only the best‐documented negative regulator of the p53 tumor suppressor …

Inactivation of the tumor suppressor p53 and/or overexpression of the oncogene MDM2
frequently occur in human cancers, and are associated with poor prognosis, advanced forms …

The PI3K/Akt signaling pathway is a major driving force in a variety of cellular functions.
Dysregulation of this pathway has been implicated in many human diseases including …

Since the discovery of the first MDM2 inhibitors, we have gained deeper insights into the
cellular roles of MDM2 and p53. In this review, we focus on MDM2 inhibitors that bind to the …