The efficacy and synthetic versatility of asymmetric organocatalysis have contributed
enormously to the field of organic synthesis since the early 2000s. As asymmetric …

The application of polystyrene-immobilized proline-based catalysts in packed-bed reactors
for the continuous-flow, direct, enantioselective α-aminoxylation of aldehydes is described …

A tandem reaction of in situ generated α-amino aldehydes with dimethyloxosulfonium
methylide under Corey–Chaykovsky reaction conditions proceeds efficiently to give 4 …

A new enantioselective synthesis of two important fungal metabolites,(+)-stagonolide C and
(−)-aspinolide A, has been described from readily available raw materials. Proline catalyzed …

A method of incorporating bulky α, β-dehydroamino acids such as dehydrovaline and
dehydroethylnorvaline into peptides via solid-phase peptide synthesis is reported. The key …

A new enantioselective synthesis of the anti-influenza agent (−)-oseltamivir free base (7.1%
overall yield; 98% ee) and (−)-methyl 3-epi-shikimate (16% overall yield; 98% ee) has been …

A new synthesis of cytotoxic anhydrophytosphingosine 3-epi-jaspine B (34.7% overall yield;
97% ee) and (+)-oxybiotin (21.2% overall yield; 97% ee), bioactive oxygen analogue of …

An efficient approach to (2S, 3S)-3-hydroxypipecolic acid with an overall yield of 10.2% and
98% ee starting from 1, 5-pentanediol has been developed. The key steps employed in the …

An environmentally benign approach involving Pd-catalyzed reductive Nsingle bondN bond
cleavage in dibenzyl-1-alkylhydrazine-1, 2-dicarboxylates leading to the synthesis of N-(tert …

A new, sequential proline-catalyzed approach to the synthesis of (+)-L-733,060 and (+)-T-
2328 in high optical purity (93% ee) is described starting from phenyl N-Boc imine. The …