Cardiac changes in Parkinson's disease: lessons from clinical and experimental evidence

L Cuenca-Bermejo, P Almela… - International Journal of …, 2021 - mdpi.com
Dysautonomia is a common non-motor symptom in Parkinson's disease (PD). Most
dysautonomic symptoms appear due to alterations in the peripheral nerves of the autonomic …

Autonomic dysfunction in Parkinson disease and animal models

JM Metzger, ME Emborg - Clinical Autonomic Research, 2019 - Springer
Parkinson disease has traditionally been classified as a movement disorder, despite
patients' accounts of diverse symptoms stemming from impairments in numerous body …

Altered cardiorespiratory regulation during exercise in patients with Parkinson's disease: A challenging non-motor feature

JL Sabino-Carvalho, LC Vianna - SAGE Open Medicine, 2020 - journals.sagepub.com
The incidence of Parkinson's disease is increasing worldwide. The motor dysfunctions are
the hallmark of the disease, but patients also experience non-motor impairments, and over …

[HTML][HTML] Baicalin attenuated substantia nigra neuronal apoptosis in Parkinson's disease rats via the mTOR/AKT/GSK-3β pathway

H Zhai, Z Kang, H Zhang, J Ma, G Chen - Journal of integrative …, 2019 - imrpress.com
This focus of our research is to investigate the protective effect of Baicalin on apoptosis and
mTOR/AKT/GSK-3β pathway in substantia nigra neurons in a rat model for Parkinson's …

Propolis as a potential disease-modifying strategy in Parkinson's disease: cardioprotective and neuroprotective effects in the 6-OHDA rat model

V C. Gonçalves, D JLL Pinheiro, T de la Rosa… - Nutrients, 2020 - mdpi.com
Patients with Parkinson's disease (PD) manifest nonmotor and motor symptoms. Autonomic
cardiovascular dysregulation is a common nonmotor manifestation associated with …

Cardiovascular dysfunction associated with neurodegeneration in an experimental model of Parkinson's disease

B Falquetto, M Tuppy, SR Potje, TS Moreira… - Brain research, 2017 - Elsevier
Patients with Parkinson's disease (PD) exhibit both motor and non-motor symptoms. Among
the non-motor symptoms, cardiovascular autonomic dysfunction is frequently observed …

Risk of myocardial infarction in Parkinson's disease: A systematic review and meta‐analysis

F Nabizadeh, P Valizadeh, P Sharifi… - European Journal of …, 2023 - Wiley Online Library
Background and purpose Previous studies investigating cardiovascular disorders in patients
with Parkinson's disease (PD) showed heterogeneous results regarding whether there is a …

Therapeutic approaches to non-motor symptoms of Parkinson's disease: a current update on preclinical evidence

PDE Weerasinghe-Mudiyanselage… - Current …, 2023 - benthamdirect.com
Despite being classified as a movement disorder, Parkinson's disease (PD) is characterized
by a wide range of non-motor symptoms that significantly affect the patients' quality of life …

Baroreflex dysfunction in Parkinson's disease: integration of central and peripheral mechanisms

JL Sabino-Carvalho, B Falquetto… - Journal of …, 2021 - journals.physiology.org
The incidence of Parkinson's disease (PD) is increasing worldwide. Although the PD
hallmark is the motor impairments, nonmotor dysfunctions are now becoming more …

Propolis induces cardiac metabolism changes in 6-hydroxydopamine animal model: A dietary intervention as a potential cardioprotective approach in Parkinson's …

VC Goncalves, V Silva da Fonsêca… - Frontiers in …, 2022 - frontiersin.org
While there is sustained growth of the older population worldwide, ageing is a consistent risk
factor for neurodegenerative diseases, such as Parkinson's-disease (PD). Considered an …