Neuroinflammation mechanisms of neuromodulation therapies for anxiety and depression

B Guo, M Zhang, W Hao, Y Wang, T Zhang… - Translational …, 2023 - nature.com
Mood disorders are associated with elevated inflammation, and the reduction of symptoms
after multiple treatments is often accompanied by pro-inflammation restoration. A variety of …

Sleep, insomnia, and depression

D Riemann, LB Krone, K Wulff, C Nissen - Neuropsychopharmacology, 2020 - nature.com
Since ancient times it is known that melancholia and sleep disturbances co-occur. The
introduction of polysomnography into psychiatric research confirmed a disturbance of sleep …

Circuits and functions of the lateral habenula in health and in disease

H Hu, Y Cui, Y Yang - Nature Reviews Neuroscience, 2020 - nature.com
The past decade has witnessed exponentially growing interest in the lateral habenula (LHb)
owing to new discoveries relating to its critical role in regulating negatively motivated …

Neural mechanism underlying depressive-like state associated with social status loss

Z Fan, J Chang, Y Liang, H Zhu, C Zhang, D Zheng… - Cell, 2023 - cell.com
Downward social mobility is a well-known mental risk factor for depression, but its neural
mechanism remains elusive. Here, by forcing mice to lose against their subordinates in a …

Hypothalamus-habenula potentiation encodes chronic stress experience and drives depression onset

Z Zheng, C Guo, M Li, L Yang, P Liu, X Zhang, Y Liu… - Neuron, 2022 - cell.com
Chronic stress is a major risk factor for depression onset. However, it remains unclear how
repeated stress sculpts neural circuits and finally elicits depression. Given the essential role …

Astrocytic lactate dehydrogenase A regulates neuronal excitability and depressive-like behaviors through lactate homeostasis in mice

S Yao, MD Xu, Y Wang, ST Zhao, J Wang… - Nature …, 2023 - nature.com
Alterations in energy metabolism are associated with depression. However, the role of
glycolysis in the pathogenesis of depression and the underlying molecular mechanisms …

Feature detection by retinal ganglion cells

D Kerschensteiner - Annual review of vision science, 2022 - annualreviews.org
Retinal circuits transform the pixel representation of photoreceptors into the feature
representations of ganglion cells, whose axons transmit these representations to the brain …

Diversity of intrinsically photosensitive retinal ganglion cells: circuits and functions

ML Aranda, TM Schmidt - Cellular and Molecular Life Sciences, 2021 - Springer
The melanopsin-expressing, intrinsically photosensitive retinal ganglion cells (ipRGCs) are
a relatively recently discovered class of atypical ganglion cell photoreceptor. These ipRGCs …

Melanopsin and the intrinsically photosensitive retinal ganglion cells: biophysics to behavior

MTH Do - Neuron, 2019 - cell.com
The mammalian visual system encodes information over a remarkable breadth of
spatiotemporal scales and light intensities. This performance originates with its complement …

The role of gamma oscillations in central nervous system diseases: Mechanism and treatment

A Guan, S Wang, A Huang, C Qiu, Y Li, X Li… - Frontiers in cellular …, 2022 - frontiersin.org
Gamma oscillation is the synchronization with a frequency of 30–90 Hz of neural
oscillations, which are rhythmic electric processes of neuron groups in the brain. The …