Diffuse myocardial fibrosis: mechanisms, diagnosis and therapeutic approaches

B López, S Ravassa, MU Moreno, GS José… - Nature Reviews …, 2021 - nature.com
Diffuse myocardial fibrosis resulting from the excessive deposition of collagen fibres through
the entire myocardium is encountered in a number of chronic cardiac diseases. This lesion …

Opportunities for microRNAs in the crowded field of cardiovascular biomarkers

PV Halushka, AJ Goodwin… - Annual Review of …, 2019 - annualreviews.org
Cardiovascular diseases exist across all developed countries. Biomarkers that can predict or
diagnose diseases early in their pathogeneses can reduce their morbidity and mortality in …

Non-coding RNAs: update on mechanisms and therapeutic targets from the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart

C Bär, S Chatterjee, I Falcão Pires… - Cardiovascular …, 2020 - academic.oup.com
Vast parts of mammalian genomes are actively transcribed, predominantly giving rise to non-
coding RNA (ncRNA) transcripts including microRNAs, long ncRNAs, and circular RNAs …

M2 bone marrow-derived macrophage-derived exosomes shuffle microRNA-21 to accelerate immune escape of glioma by modulating PEG3

F Yang, T Wang, P Du, H Fan, X Dong, H Guo - Cancer Cell International, 2020 - Springer
Background Growing studies have focused on the role of microRNA-21 (miR-21) in glioma,
thus our objective was to discuss the effect of M2 bone marrow-derived macrophage …

Cardiac fibrosis is a risk factor for severe COVID-19

J Mustroph, J Hupf, MJ Baier, K Evert… - Frontiers in …, 2021 - frontiersin.org
Increased left ventricular fibrosis has been reported in patients hospitalized with coronavirus
disease 2019 (COVID-19). It is unclear whether this fibrosis is a consequence of severe …

Myocardial tissue characterisation using echocardiographic deformation imaging

MA Moharram, RR Lamberts, G Whalley… - Cardiovascular …, 2019 - Springer
Myocardial pathology results in significant morbidity and mortality, whether due to primary
cardiomyopathic processes or secondary to other conditions such as ischemic heart …

[HTML][HTML] Bone marrow-derived mesenchymal stem cells overexpressing MiR-21 efficiently repair myocardial damage in rats

YL Zeng, H Zheng, QR Chen, XH Yuan, JH Ren… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Objective We investigated the ability of bone marrow derived mesenchymal stem cells
(BMSCs) overexpressing microRNA-21 (miR-21) to repair cardiac damage induced by …

Severe aortic valve stenosis and pulmonary hypertension: a systematic review of non-invasive ways of risk stratification, especially in patients undergoing …

E Boxhammer, AE Berezin, V Paar, N Bacher… - Journal of Personalized …, 2022 - mdpi.com
Patients with severe aortic valve stenosis and concomitant pulmonary hypertension show a
significantly reduced survival prognosis. Right heart catheterization as a preoperative …

Growth differentiation factor 15 in severe aortic valve stenosis: relationship with left ventricular remodeling and frailty

I Fabiani, T Santoni, M Angelillis, S Petricciuolo… - Journal of clinical …, 2020 - mdpi.com
Background: Frailty is an important outcome predictor in patients with aortic stenosis who
are candidates for transcatheter or surgical aortic valve replacement (AVR) …

Non-coding RNAs as blood-based biomarkers in cardiovascular disease

RF Videira, PA da Costa Martins… - International journal of …, 2020 - mdpi.com
In 2020, cardiovascular diseases (CVDs) remain a leading cause of mortality and morbidity,
contributing to the burden of the already overloaded health system. Late or incorrect …