The endothelium can evoke relaxations of the underlying vascular smooth muscle, by
releasing vasodilator substances. The best‐characterized endothelium‐derived relaxing …

The endothelium can evoke relaxations (dilatations) of the underlying vascular smooth
muscle, by releasing vasodilator substances. The best characterized endothelium‐derived …

Obesity is a metabolic disorder of increasing prevalence worldwide and a risk factor for the
development of insulin resistance (IR), metabolic syndrome and type 2 diabetes. Obesity is …

Maternal obesity is associated with increased morbidity and mortality for both mother and
offspring. The mechanisms underlying the increased risk associated with maternal obesity …

Abstract Endothelin-1 (ET-1) is involved in the regulation of a myriad of processes highly
relevant for physical and mental well-being; female and male health; in the modulation of …

One of the most profound challenges facing public health and public health policy in
Western society is the increased incidence and prevalence of both overweight and obesity …

Diabetes is a worldwide health issue closely associated with cardiovascular events. Given
the pandemic of obesity, the identification of the basic underpinnings of vascular disease is …

Endothelial cells (ECs) maintain the health of blood vessels and prevent the development of
cardiovascular disease (CVD). Free saturated fatty acids (FAs) induce EC damage and …

Obesity is an ongoing worldwide epidemic. Besides being a medical condition in itself,
obesity dramatically increases the risk of development of metabolic and cardiovascular …

Obesity is characterized by pathological adipose tissue (AT) expansion. While healthy AT
expansion enhances systemic insulin sensitivity, unhealthy AT expansion through increased …