The unceasing circulation of SARS-CoV-2 leads to the continuous emergence of novel viral
sublineages. Here, we isolate and characterize XBB. 1, XBB. 1.5, XBB. 1.9. 1, XBB. 1.16. 1 …

Variant BA. 2.86 and its descendant, JN. 1, of SARS-CoV-2 are rising in incidence across
Europe and globally. We isolated recent JN. 1, BA. 2.86, EG. 5, XBB. 1.5 and earlier variants …

We investigate JN. 1-derived subvariants SLip, FLiRT, and KP. 2 for neutralization by
antibodies in vaccinated individuals, severe acute respiratory syndrome coronavirus 2 …

Beginning in 2022, following widespread infection and vaccination among the global
population, the SARS-CoV-2 virus mainly evolved to evade immunity derived from vaccines …

Abstract SARS-CoV-2 JN. 1 with an additional L455S mutation on spike when compared
with its parental variant BA. 2.86 has outcompeted all earlier variants to become the …

Deep mutational scanning experiments aid in the surveillance and forecasting of viral
evolution by providing prospective measurements of mutational effects on viral traits, but …

Due to the incessant emergence of various SARS-CoV-2 variants with enhanced fitness in
the human population, controlling the COVID-19 pandemic has been challenging …

The most recent wave of SARS-CoV-2 Omicron variants descending from BA. 2 and BA.
2.86 exhibited improved viral growth and fitness due to convergent evolution of functional …

SARS-CoV-2 variants are mainly defined by mutations in their spike. It is therefore critical to
understand how the evolutionary trajectories of spike affect virus phenotypes. So far, it has …

SUMMARY SARS-CoV-2 variants derived from the immune evasive JN. 1 are on the rise
worldwide. Here, we investigated JN. 1-derived subvariants SLip, FLiRT, and KP. 2 for their …