New Insights into the Cooperativity and Dynamics of Dimeric Enzymes
KW Chen, TY Sun, YD Wu - Chemical Reviews, 2023 - ACS Publications
A survey of protein databases indicates that the majority of enzymes exist in oligomeric
forms, with about half of those found in the UniProt database being homodimeric …
forms, with about half of those found in the UniProt database being homodimeric …
Rational design, bio-functionalization and biological performance of hybrid additive manufactured titanium implants for orthopaedic applications: A review
Evolution of metallurgy and biomaterials has progressively shifted the focus of metallic bone-
interfacing implant design from adequate mechanical strength and biocompatibility to rapid …
interfacing implant design from adequate mechanical strength and biocompatibility to rapid …
Interference with quorum-sensing signal biosynthesis as a promising therapeutic strategy against multidrug-resistant pathogens
O Fleitas Martínez, PO Rigueiras, AS Pires… - Frontiers in cellular …, 2019 - frontiersin.org
Faced with the global health threat of increasing resistance to antibiotics, researchers are
exploring interventions that target bacterial virulence factors. Quorum sensing is a …
exploring interventions that target bacterial virulence factors. Quorum sensing is a …
Immucillins in infectious diseases
The Immucillins are chemically stable analogues that mimic the ribocation and leaving-
group features of N-ribosyltransferase transition states. Infectious disease agents often rely …
group features of N-ribosyltransferase transition states. Infectious disease agents often rely …
Revisiting the methionine salvage pathway and its paralogues
A Sekowska, H Ashida, A Danchin - Microbial biotechnology, 2019 - Wiley Online Library
Methionine is essential for life. Its chemistry makes it fragile in the presence of oxygen.
Aerobic living organisms have selected a salvage pathway (the MSP) that uses dioxygen to …
Aerobic living organisms have selected a salvage pathway (the MSP) that uses dioxygen to …
Evaluation of novel quorum sensing inhibitors targeting auto-inducer 2 (AI-2) for the control of avian pathogenic Escherichia coli infections in chickens
Avian pathogenic Escherichia coli (APEC) associated with colibacillosis results in high
morbidity and mortality, and severe economic losses to the poultry industry. APEC is a …
morbidity and mortality, and severe economic losses to the poultry industry. APEC is a …
Combined infection control and enhanced osteogenic differentiation capacity on additive manufactured Ti‐6Al‐4V are mediated via titania nanotube delivery of novel …
Additive manufacturing (AM) of titanium alloys offers the capacity to fabricate patient‐specific
implants with defined porous architecture to enhance bone‐implant fixation. However …
implants with defined porous architecture to enhance bone‐implant fixation. However …
Narrow-spectrum antibiotic targeting of the radical SAM enzyme MqnE in menaquinone biosynthesis
Antibiotic resistance continues to spread at an alarming rate, outpacing the introduction of
new therapeutics and threatening to globally undermine health care. There is a crucial need …
new therapeutics and threatening to globally undermine health care. There is a crucial need …
Antibacterial Strategy against H. pylori: Inhibition of the Radical SAM Enzyme MqnE in Menaquinone Biosynthesis
Aminofutalosine synthase (MqnE) catalyzes an important rearrangement reaction in
menaquinone biosynthesis by the futalosine pathway. In this Letter, we report the …
menaquinone biosynthesis by the futalosine pathway. In this Letter, we report the …
Residence times for femtomolar and picomolar inhibitors of MTANs
M Brown, PC Tyler, VL Schramm - Biochemistry, 2023 - ACS Publications
5′-Methylthioadenosine nucleosidases (MTANs) catalyze the hydrolysis of 5′-substituted
adenosines to form adenine and 5-substituted ribose. Escherichia coli MTAN (Ec MTAN) …
adenosines to form adenine and 5-substituted ribose. Escherichia coli MTAN (Ec MTAN) …