Cystic fibrosis and Pseudomonas aeruginosa: the host-microbe interface

S Malhotra, D Hayes Jr, DJ Wozniak - Clinical microbiology …, 2019 - Am Soc Microbiol
In human pathophysiology, the clash between microbial infection and host immunity
contributes to multiple diseases. Cystic fibrosis (CF) is a classical example of this …

How melittin inserts into cell membrane: conformational changes, inter-peptide cooperation, and disturbance on the membrane

J Hong, X Lu, Z Deng, S Xiao, B Yuan, K Yang - Molecules, 2019 - mdpi.com
Antimicrobial peptides (AMPs), as a key component of the immune defense systems of
organisms, are a promising solution to the serious threat of drug-resistant bacteria to public …

Hydrophobicity determines the bacterial killing rate of α-helical antimicrobial peptides and influences the bacterial resistance development

M Zhang, J Ouyang, L Fu, C Xu, Y Ge… - Journal of medicinal …, 2022 - ACS Publications
Rapid antimicrobial action is an important advantage of antimicrobial peptides (AMPs) over
antibiotics, which is also a reason for AMPs being less likely to induce bacterial resistance …

Helicity-directed recognition of bacterial phospholipid via radially amphiphilic antimicrobial peptides

Y Liang, Y Zhang, Y Huang, C Xu, J Chen, X Zhang… - Science …, 2024 - science.org
The fundamental differences in phospholipids between bacterial and mammalian cell
membranes present remarkable opportunities for antimicrobial design. However, it is …

Review of antimicrobial peptides as promoters of food safety: Limitations and possibilities within the food industry

A Leon Madrazo, MR Segura Campos - Journal of Food Safety, 2020 - Wiley Online Library
Antimicrobial peptides (AMPs) are a group of molecules that has gained interest in research
due to their important role in the inhibition of bacterial agents. Their structure shows …

Rigidification of the Escherichia coli cytoplasm by the human antimicrobial peptide LL-37 revealed by superresolution fluorescence microscopy

Y Zhu, S Mohapatra… - Proceedings of the …, 2019 - National Acad Sciences
Superresolution, single-particle tracking reveals effects of the cationic antimicrobial peptide
LL-37 on the Escherichia coli cytoplasm. Seconds after LL-37 penetrates the cytoplasmic …

Helical structure motifs made searchable for functional peptide design

CY Tsai, EO Salawu, H Li, GY Lin, TY Kuo… - Nature …, 2022 - nature.com
The systematic design of functional peptides has technological and therapeutic applications.
However, there is a need for pattern-based search engines that help locate desired …

Membrane potential drives direct translocation of cell-penetrating peptides

X Gao, S Hong, Z Liu, T Yue, J Dobnikar, X Zhang - Nanoscale, 2019 - pubs.rsc.org
Cell-penetrating peptides (CPPs) are frequently employed as drug delivery agents with
rapid cellular uptake, however, the uptake mechanism and the detailed translocation …

Time-resolved fluorescence and anisotropy-sensitive 1, 2-dimyristoyl-sn-glycero-3-(7-aminocoumarin) phosphoetanolamide probe for studying membrane lipid …

D Zúñiga-Núñez, F Mura, N Mariño-Ocampo… - Dyes and …, 2023 - Elsevier
Abstract A fluorescent probe C-DMPE was synthesised to monitor interfacial membrane
properties by conjugating coumarin-343 and 1, 2-dimyristoyl-sn-glycero-3 …

Correlation between single-molecule dynamics and biological functions of antimicrobial peptide melittin

C Xu, W Ma, K Wang, K He, Z Chen, J Liu… - The Journal of …, 2020 - ACS Publications
Many fundamental biological processes occur on cell membranes, and a typical example is
the membrane permeabilization by peptides for an antimicrobial purpose. Previous studies …