Introduction: There is a clinical need for pharmaceutical dosage forms devised to prolong
the acting time of local anesthetic (LA) agents or to reduce their toxicity. Encapsulation of LA …

Cyclodextrins are present in a variety of oral hygiene compositions. The present work
describes the role of cyclodextrins in several toothpastes and mouthwashes that are already …

Previously, we have demonstrated the analgesic-like property of p-cymene in rodents. Short
half-life is a limitation for p-cymene application and several approaches have been used to …

Abstract Many plants produce (−)‐linalool, a plant‐derived monoterpene alcohol, including
members of the L amiaceae (mints) and L auraceae family (laurels, cinnamon, rosewood) …

Tetracaine (TTC) is a local anesthetic broadly used for topical and spinal blockade, despite
its systemic toxicity. Encapsulation in nanostructured lipid carriers (NLC) may prolong TTC …

Introduction: Topical anesthesia is widely used in dentistry to reduce pain caused by needle
insertion and injection of the anesthetic. However, successful anesthesia is not always …

Introduction: One of the most common strategies for pain control during and after surgical
procedures is the use of local anesthetics. Prolonged analgesia can be safely achieved with …

Introduction: Analgesics can be ineffective in treating some types of pain, hence, improved
drug delivery systems could optimize their efficacy. Area covered: The authors conducted a …

The paper focuses on the advances in the field of pain treatment by transdermal delivery of
specific drugs. Starting from a short description of the skin barrier, the pharmacodynamics …

Bupivacaine hydrochloride (BVC) represents an option to produce long-lasting analgesia,
and complexation in cyclodextrins has shown improvements in biopharmaceutical …