Cellular infiltration in traumatic brain injury

A Alam, EP Thelin, T Tajsic, DZ Khan, A Khellaf… - Journal of …, 2020 - Springer
Traumatic brain injury leads to cellular damage which in turn results in the rapid release of
damage-associated molecular patterns (DAMPs) that prompt resident cells to release …

Traumatic brain injury: current treatment strategies and future endeavors

M Galgano, G Toshkezi, X Qiu, T Russell… - Cell …, 2017 - journals.sagepub.com
Traumatic brain injury (TBI) presents in various forms ranging from mild alterations of
consciousness to an unrelenting comatose state and death. In the most severe form of TBI …

Animal models of traumatic brain injury and assessment of injury severity

X Ma, A Aravind, BJ Pfister, N Chandra… - Molecular neurobiology, 2019 - Springer
Traumatic brain injury (TBI) contributes a major cause of death, disability, and mental health
disorders. Most TBI patients suffer long-term post-traumatic stress disorder, cognitive …

Animal models of traumatic brain injury

Y Xiong, A Mahmood, M Chopp - Nature Reviews Neuroscience, 2013 - nature.com
Traumatic brain injury (TBI) is a leading cause of mortality and morbidity both in civilian life
and on the battlefield worldwide. Survivors of TBI frequently experience long-term disabling …

Pathophysiology associated with traumatic brain injury: current treatments and potential novel therapeutics

ML Pearn, IR Niesman, J Egawa, A Sawada… - Cellular and molecular …, 2017 - Springer
Traumatic brain injury (TBI) is one of the leading causes of death of young people in the
developed world. In the United States alone, 1.7 million traumatic events occur annually …

Pathogenesis of brain edema and investigation into anti-edema drugs

S Michinaga, Y Koyama - International journal of molecular sciences, 2015 - mdpi.com
Brain edema is a potentially fatal pathological state that occurs after brain injuries such as
stroke and head trauma. In the edematous brain, excess accumulation of extracellular fluid …

Classification of traumatic brain injury for targeted therapies

KE Saatman, AC Duhaime, R Bullock… - Journal of …, 2008 - liebertpub.com
The heterogeneity of traumatic brain injury (TBI) is considered one of the most significant
barriers to finding effective therapeutic interventions. In October, 2007, the National Institute …

Repeated mild traumatic brain injury: potential mechanisms of damage

B Fehily, M Fitzgerald - Cell transplantation, 2017 - journals.sagepub.com
Mild traumatic brain injury (mTBI) represents a significant public healthcare concern,
accounting for the majority of all head injuries. While symptoms are generally transient …

Traumatic brain injury in older adults: epidemiology, outcomes, and future implications

HJ Thompson, WC McCormick… - Journal of the American …, 2006 - Wiley Online Library
Traumatic brain injury (TBI) is a significant problem in older adults. In persons aged 65 and
older, TBI is responsible for more than 80,000 emergency department visits each year; three …

Mouse closed head injury model induced by a weight-drop device

MA Flierl, PF Stahel, KM Beauchamp, SJ Morgan… - Nature protocols, 2009 - nature.com
Traumatic brain injury represents the leading cause of death in young individuals. Various
animal models have been developed to mimic human closed head injury (CHI). Widely used …