This review assesses the parallel data on the role of gamma‐aminobutyric acid (GABA) in
depression and anxiety. We review historical and new data from both animal and human …

The past decade has brought many advances in our understanding of GABA A receptor-
mediated ethanol action in the central nervous system. We now know that specific GABA A …

Alcoholism is a common, heritable, chronic relapsing disorder. GABAA receptors undergo
allosteric modulation by ethanol, anesthetics, benzodiazepines and neurosteroids and have …

Context Alcohol facilitates γ-aminobutyric acid (GABA) function, and GABA type A (GABA A)
receptor–facilitating agents suppress alcohol withdrawal symptoms. Advances in molecular …

Finasteride is the first 5α‐reductase inhibitor that received clinical approval for the treatment
of human benign prostatic hyperplasia (BPH) and androgenetic alopecia (male pattern hair …

Baicalein (BA), one of the main flavonoids obtained from the Chinese medicinal herb
Scutellaria baicalensis, usually exerts several pharmacological effects. In the central …

Sex differences in patterns of drinking and rates of alcohol abuse and dependence begin to
emerge during the transition from late puberty to young adulthood. Increases in pubertal …

This special issue heralds an exciting time in the field when the significance of neuroactive
steroids in the regulation of inhibitory transmission is being realized and translated to new …

Rodent defense behavior assays have been widely used as preclinical models of anxiety to
study possibly therapeutic anxiety-reducing interventions. However, some proposed anxiety …

The enzyme steroid 5α-reductase (S5αR) catalyzes the conversion of Δ4-3-ketosteroid
precursors-such as testosterone, progesterone and androstenedione-into their 5α-reduced …