The past decade has brought many advances in our understanding of GABA A receptor- mediated ethanol action in the central nervous system. We now know that specific GABA A …
MA Enoch - Pharmacology Biochemistry and Behavior, 2008 - Elsevier
Alcoholism is a common, heritable, chronic relapsing disorder. GABAA receptors undergo allosteric modulation by ethanol, anesthetics, benzodiazepines and neurosteroids and have …
JH Krystal, J Staley, G Mason, IL Petrakis… - Archives of general …, 2006 - jamanetwork.com
Context Alcohol facilitates γ-aminobutyric acid (GABA) function, and GABA type A (GABA A) receptor–facilitating agents suppress alcohol withdrawal symptoms. Advances in molecular …
DA Finn, AS Beadles‐Bohling, EH Beckley… - CNS drug …, 2006 - Wiley Online Library
Finasteride is the first 5α‐reductase inhibitor that received clinical approval for the treatment of human benign prostatic hyperplasia (BPH) and androgenetic alopecia (male pattern hair …
RSM de Carvalho, FS Duarte, TCM de Lima - Behavioural brain research, 2011 - Elsevier
Baicalein (BA), one of the main flavonoids obtained from the Chinese medicinal herb Scutellaria baicalensis, usually exerts several pharmacological effects. In the central …
ED Witt - Neurotoxicology and teratology, 2007 - Elsevier
Sex differences in patterns of drinking and rates of alcohol abuse and dependence begin to emerge during the transition from late puberty to young adulthood. Increases in pubertal …
AL Morrow - Pharmacology & therapeutics, 2007 - Elsevier
This special issue heralds an exciting time in the field when the significance of neuroactive steroids in the regulation of inhibitory transmission is being realized and translated to new …
Rodent defense behavior assays have been widely used as preclinical models of anxiety to study possibly therapeutic anxiety-reducing interventions. However, some proposed anxiety …
S Paba, R Frau, SC Godar, P Devoto… - Current …, 2011 - ingentaconnect.com
The enzyme steroid 5α-reductase (S5αR) catalyzes the conversion of Δ4-3-ketosteroid precursors-such as testosterone, progesterone and androstenedione-into their 5α-reduced …