Reactive oxygen species (ROS) and free radicals are essential for transmission of cell
signals and other physiological functions. However, excessive amounts of ROS can cause …

The development, maintenance of healthy bone and regeneration of injured tissue in the
human body comprise a set of intricate and finely coordinated processes. However, an …

The demand for organ transplantation and repair, coupled with a shortage of available
donors, poses an urgent clinical need for the development of innovative treatment strategies …

In the tissue engineering (TE) paradigm, engineering and life sciences tools are combined
to develop bioartificial substitutes for organs and tissues, which can in turn be applied in …

Organ-on-a-chip (OOAC) is an emerging technology based on microfluid platforms and in
vitro cell culture that has a promising future in the healthcare industry. The numerous …

Disruption of bone remodelling by diseases such as osteoporosis results in an imbalance
between bone formation by osteoblasts and resorption by osteoclasts. Research into these …

Bone is an extremely dynamic tissue, undergoing continuous remodeling for its whole
lifetime, but its regeneration or augmentation due to bone loss or defects are not always …

Bone remodelling is a dynamic process required for the maintenance of bone architecture in
response to the changing mechanical needs. It is also a vital process during the repair of …

Hydrogels based on natural polymers offer a range of properties to mimic the native
extracellular matrix, and provide microenvironments to preserve cellular function and …

The synovium of osteoarthritis (OA) patients can be characterized by an abnormal
accumulation of macrophages originating from extravasated monocytes. Since targeting …