Myeloid malignancies are devastating hematologic cancers with limited therapeutic options.
Inflammation is emerging as a novel driver of myeloid malignancy, with important …

Hematopoietic stem cells (HSCs) are known for their significant capability to reconstitute and
preserve a functional hematopoietic system in long-term periods after transplantation into …

Myeloid cell infiltration of solid tumours generally associates with poor patient prognosis and
disease severity,,,,,,,,,,,–. Therefore, understanding the regulation of myeloid cell …

Systemic inflammatory and autoimmune diseases and myelodysplastic syndromes have
been linked in individual patients and in larger case series for at least 25 years. These …

Mechanisms of prolonged cytopenia (PC) after chimeric antigen receptor (CAR) T‐cell
therapy, an emerging therapy for relapsed or refractory diffuse large B‐cell lymphoma …

Cancer initiation is orchestrated by an interplay between tumor-initiating cells and their
stromal/immune environment. Here, by adapted single-cell RNA sequencing, we decipher …

Haematopoietic stem cells (HSCs) reside in the bone marrow and are supported by the
specialised microenvironment, a niche to maintain HSC quiescence. To deal with …

Hematopoiesis is a remarkable system that plays an important role in not only immune cell
function, but also in nutrient transport, hemostasis and wound healing among other …

Chronic inflammation represents a major threat to human health since long‐term systemic
inflammation is known to affect distinct tissues and organs. Recently, solid evidence …

Bone marrow–derived mesenchymal stem cells (BMSCs) support bone formation and
constitute the stromal niche in regulating hematopoietic stem cells (HSCs). Stromal niche …