The substrates used to modify nucleic acids and chromatin are affected by nutrient
availability and the activity of metabolic pathways. Thus, cellular metabolism constitutes a …

Metalloenzymes are central to a wide range of essential biological activities, including
nucleic acid modification, protein degradation, and many others. The role of metalloenzymes …

Epigenetic regulation of gene expression is a dynamic and reversible process that
establishes normal cellular phenotypes but also contributes to human diseases. At the …

Mutations in isocitrate dehydrogenases (IDHs) have a gain‐of‐function effect leading to R
(−)‐2‐hydroxyglutarate (R‐2HG) accumulation. By using biochemical, structural and cellular …

Post-translational modifications of histones by protein methyltransferases (PMTs) and
histone demethylases (KDMs) play an important role in the regulation of gene expression …

How cells sense and respond to environmental cues remains a central question of biological
research. Recent evidence suggests that DNA transcription is regulated by chromatin …

It has recently been demonstrated that the genes controlling the epigenetic programmes that
are required for maintaining chromatin structure and cell identity include genes that drive …

Activation of oncogenes or the deactivation of tumor suppressor genes has long been
established as the fundamental mechanism leading towards carcinogenesis. Although this …

Histone methylation is a key posttranslational modification of chromatin, and its
dysregulation affects a wide array of nuclear activities including the maintenance of genome …

While the oxygen-dependent reversal of lysine N ɛ-methylation is well established, the
existence of bona fide N ω-methylarginine demethylases (RDMs) is controversial. Lysine …