Strategies for the development of glycomimetic drug candidates

R Hevey - Pharmaceuticals, 2019 - mdpi.com
Carbohydrates are a structurally-diverse group of natural products which play an important
role in numerous biological processes, including immune regulation, infection, and cancer …

Endothelial progenitor cells dysfunctions and cardiometabolic disorders: from mechanisms to therapeutic approaches

AC Peyter, JB Armengaud, E Guillot… - International Journal of …, 2021 - mdpi.com
Metabolic syndrome (MetS) is a cluster of several disorders, such as hypertension, central
obesity, dyslipidemia, hyperglycemia, insulin resistance and non-alcoholic fatty liver …

Therapeutic potential of endothelial colony-forming cells in ischemic disease: strategies to improve their regenerative efficacy

P Faris, S Negri, A Perna, V Rosti, G Guerra… - International journal of …, 2020 - mdpi.com
Cardiovascular disease (CVD) comprises a range of major clinical cardiac and circulatory
diseases, which produce immense health and economic burdens worldwide. Currently …

[HTML][HTML] Novel Glycomimetics Protect against Glycated Low-Density Lipoprotein-Induced Vascular Calcification In Vitro via Attenuation of the RAGE/ERK/CREB …

GP Sidgwick, R Weston, AM Mahmoud, A Schiro… - Cells, 2024 - mdpi.com
Heparan sulphate (HS) can act as a co-receptor on the cell surface and alterations in this
process underpin many pathological conditions. We have previously described the …

[HTML][HTML] Origins and functional differences of blood endothelial cells

CY Ng, C Cheung - Seminars in Cell & Developmental Biology, 2024 - Elsevier
The interests in blood endothelial cells arise from their therapeutic potential in vascular
repair and regeneration. Our understanding of blood endothelial cells that exist in the …

Recent advances in endothelial colony-forming cells: from the transcriptomic perspective

Y Liu, CJ Lyons, C Ayu, T O'Brien - Journal of Translational Medicine, 2024 - Springer
Endothelial colony-forming cells (ECFCs) are progenitors of endothelial cells with significant
proliferative and angiogenic ability. ECFCs are a promising treatment option for various …

Enhancing endothelial colony-forming cells for treating diabetic vascular complications: Challenges and clinical prospects

Y Liu, CJ Lyons, C Ayu, T O'Brien - Frontiers in Endocrinology, 2024 - pmc.ncbi.nlm.nih.gov
Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia, leading to
various vascular complications. Accumulating evidence indicates that endothelial colony …

The modulatory role of sulfated and non-sulfated small molecule heparan sulfate-glycomimetics in endothelial dysfunction: Absolute structural clarification, molecular …

DM Gill, APR Povinelli, G Zazeri, SA Shamir… - RSC medicinal …, 2021 - pubs.rsc.org
The conceptual technology of small molecule glycomimetics, exemplified by compounds C1–
4, has shown promising protective effects against lipid-induced endothelial dysfunction …

Exploring Endothelial Colony‐Forming Cells to Better Understand the Pathophysiology of Disease: An Updated Review

Q Zhang, A Cannavicci, MJB Kutryk - Stem Cells International, 2022 - Wiley Online Library
Endothelial cell (EC) dysfunction has been implicated in a variety of pathological conditions.
The collection of ECs from patients is typically conducted postmortem or through invasive …

Endothelial Colony-Forming Cells (ECFCs) in Cerebrovascular Aging: Focus on the Pathogenesis of Vascular Cognitive Impairment and Dementia (VCID), and …

S Negri, Z Reyff, E Troyano-Rodriguez, M Milan… - Ageing Research …, 2025 - Elsevier
Endothelial colony-forming cells (ECFCs), a unique endothelial progenitor subset, are
essential for vascular integrity and repair, providing significant regenerative potential …