Immunoglobulins couple the recognition of invading pathogens with the triggering of potent
effector mechanisms for pathogen elimination. Different immunoglobulin classes trigger …

Immunoglobulins (Igs) play key roles in immune protection of mucosal surfaces that form an
immense and vulnerable interface with the environment. In humans, the principal Ig in most …

Antibody therapy of cancer is increasingly used in the clinic and has improved patient's life
expectancy. Except for immune checkpoint inhibition, the mode of action of many antibodies …

Abstract Immunoglobulin-α (IgA)-bound antigens induce immune effector responses by
activating the IgA-specific receptor FcαRI (CD89) on immune cells. Here we present crystal …

Hospital-acquired bacterial infections are an increasingly important cause of morbidity and
mortality worldwide. Staphylococcal species are responsible for the majority of hospital …

HLA-G is a nonclassical major histocompatibility complex class I (MHCI) molecule, which is
expressed in trophoblasts and confers immunological tolerance in the maternal-fetal …

Immunoglobulin Y (IgY) is central to our understanding of immunoglobulin evolution. It has
links to antibodies from the ancestral IgM to the mucosal IgX and IgA, as well as to …

The human microbiome is a complex and dynamic system that plays important roles in
human health and disease. However, there remain limitations and theoretical gaps in our …

Activation of circulating platelets by exposed vessel wall collagen is a primary step in the
pathogenesis of heart attack and stroke, and drugs to block platelet activation have …

Inflammatory lung diseases represent a persistent burden for patients and the global
healthcare system. The combination of high morbidity,(partially) high mortality and limited …