[HTML][HTML] The molecular basis of mammary gland development and epithelial differentiation

PF Slepicka, AVH Somasundara… - Seminars in cell & …, 2021 - Elsevier
Our understanding of the molecular events underpinning the development of mammalian
organ systems has been increasing rapidly in recent years. With the advent of new and …

Mammary cell gene expression atlas links epithelial cell remodeling events to breast carcinogenesis

K Saeki, G Chang, N Kanaya, X Wu, J Wang… - Communications …, 2021 - nature.com
The female mammary epithelium undergoes reorganization during development,
pregnancy, and menopause, linking higher risk with breast cancer development. To …

Annexin A1 is a polarity cue that directs mitotic spindle orientation during mammalian epithelial morphogenesis

M Fankhaenel, FSG Hashemi, L Mourao… - Nature …, 2023 - nature.com
Oriented cell divisions are critical for the formation and maintenance of structured epithelia.
Proper mitotic spindle orientation relies on polarised anchoring of force generators to the …

Downregulation of miR-223 expression is an early event during mammary transformation and confers resistance to CDK4/6 inhibitors in luminal breast cancer

F Citron, I Segatto, GLR Vinciguerra, L Musco, F Russo… - Cancer research, 2020 - AACR
Abstract miR-223 is an anti-inflammatory miRNA that in cancer acts either as an
oncosuppressor or oncopromoter, in a context-dependent manner. In breast cancer, we …

A novel 3'‐tRNAGlu‐derived fragment acts as a tumor suppressor in breast cancer by targeting nucleolin

M Falconi, M Giangrossi, ME Zabaleta… - The FASEB …, 2019 - Wiley Online Library
tRNA‐derived fragments (tRFs) have been defined as a novel class of small noncoding
RNAs. tRFs have been reported to be deregulated in cancer, but their biologic function …

Splicing factor proline-and glutamine-rich (SFPQ) protein regulates platinum response in ovarian cancer-modulating SRSF2 activity

I Pellarin, A Dall'Acqua, A Gambelli, I Pellizzari… - Oncogene, 2020 - nature.com
In epithelial ovarian cancer (EOC), response to platinum (PT)-based chemotherapy dictates
subsequent treatments and predicts patients' prognosis. Alternative splicing is often …

HER2-displaying M13 bacteriophages induce therapeutic immunity against breast cancer

J Wang, A Lamolinara, L Conti, M Giangrossi, L Cui… - Cancers, 2022 - mdpi.com
Simple Summary The high incidence and death rates of breast cancer make the
development of new therapies an urgent need. The introduction into the clinic of the anti …

miR‐9 modulates and predicts the response to radiotherapy and EGFR inhibition in HNSCC

F Citron, I Segatto, L Musco, I Pellarin… - EMBO Molecular …, 2021 - embopress.org
Radiotherapy (RT) plus the anti‐EGFR monoclonal antibody Cetuximab (CTX) is an effective
combination therapy for a subset of head and neck squamous cell carcinoma (HNSCC) …

Stathmin expression associates with vascular and immune responses in aggressive breast cancer subgroups

C Askeland, E Wik, K Finne, E Birkeland, JB Arnes… - Scientific reports, 2020 - nature.com
Studies indicate that stathmin expression associates with PI3K activation in breast cancer,
suggesting stathmin as a marker for targetable patient subgroups. Here we assessed …

RNA splicing alteration in the response to platinum chemotherapy in ovarian cancer: A possible biomarker and therapeutic target

I Pellarin, B Belletti… - Medicinal research reviews, 2021 - Wiley Online Library
Since its discovery, alternative splicing has been recognized as a powerful way for a cell to
amplify the genetic information and for a living organism to adapt, evolve, and survive. We …