Cardiac potassium channel subtypes: new roles in repolarization and arrhythmia

N Schmitt, M Grunnet, SP Olesen - Physiological reviews, 2014 - journals.physiology.org
About 10 distinct potassium channels in the heart are involved in shaping the action
potential. Some of the K+ channels are primarily responsible for early repolarization …

Non‐coding RNA involvement in the pathogenesis of diabetic cardiomyopathy

W Zhang, W Xu, Y Feng, X Zhou - Journal of Cellular and …, 2019 - Wiley Online Library
In recent years, the incidence of diabetes has been increasing rapidly, which seriously
endangers human health. Diabetic cardiomyopathy, an important cardiovascular …

Concurrent diabetes and heart failure: interplay and novel therapeutic approaches

QG Karwi, KL Ho, S Pherwani, EB Ketema… - Cardiovascular …, 2022 - academic.oup.com
Diabetes mellitus increases the risk of developing heart failure, and the co-existence of both
diseases worsens cardiovascular outcomes, hospitalization, and the progression of heart …

[HTML][HTML] Role of microRNA in diabetic cardiomyopathy: from mechanism to intervention

R Guo, S Nair - Biochimica et biophysica acta (BBA)-molecular basis of …, 2017 - Elsevier
Diabetic cardiomyopathy is a chronic and irreversible heart complication in diabetic patients,
and is characterized by complex pathophysiologic events including early diastolic …

Cardiovascular microRNAs: as modulators and diagnostic biomarkers of diabetic heart disease

S Rawal, P Manning, R Katare - Cardiovascular diabetology, 2014 - Springer
Diabetic heart disease (DHD) is the leading cause of morbidity and mortality among the
people with diabetes, with approximately 80% of the deaths in diabetics are due to …

MicroRNA-mediated downregulation of the potassium channel Kv4. 2 contributes to seizure onset

C Gross, X Yao, T Engel, D Tiwari, L Xing, S Rowley… - Cell reports, 2016 - cell.com
Seizures are bursts of excessive synchronized neuronal activity, suggesting that
mechanisms controlling brain excitability are compromised. The voltage-gated potassium …

Pathophysiological fundamentals of diabetic cardiomyopathy

X Hu, T Bai, Z Xu, Q Liu, Y Zheng… - Comprehensive …, 2011 - Wiley Online Library
Diabetic cardiomyopathy (DCM) was first recognized more than four decades ago and
occurred independent of cardiovascular diseases or hypertension in both type 1 and type 2 …

[HTML][HTML] MicroRNA-223–3p promotes pyroptosis of cardiomyocyte and release of inflammasome factors via downregulating the expression level of SPI1 (PU. 1)

S Zhao, Y Tan, J Qin, H Xu, L Liu, H Wan, C Zhang… - Toxicology, 2022 - Elsevier
Diabetic cardiomyopathy (DCM) is a common heart disease in patients with diabetes
mellitus (DM), and is sometimes its main cause of death. Among all the causes of DCM …

[HTML][HTML] MiR-223-3p as a novel MicroRNA regulator of expression of voltage-gated K+ channel Kv4. 2 in acute myocardial infarction

X Liu, Y Zhang, W Du, H Liang, H He, L Zhang… - Cellular Physiology and …, 2016 - karger.com
Background/Aims: Acute myocardial infarction (AMI) is a devastating cardiovascular disease
with a high rate of morbidity and mortality, partly due to enhanced arrhythmogenicity …

Poorly controlled type 2 diabetes is accompanied by significant morphological and ultrastructural changes in both erythrocytes and in thrombin-generated fibrin …

E Pretorius, J Bester, N Vermeulen… - Cardiovascular …, 2015 - Springer
We have noted in previous work, in a variety of inflammatory diseases, where iron
dysregulation occurs, a strong tendency for erythrocytes to lose their normal discoid shape …