Obstructive sleep apnea syndrome (OSAS) is a common breathing disorder in sleep in
which the airways narrow or collapse during sleep, causing obstructive sleep apnea. The …

Histone lysine methylation has emerged as a critical player in the regulation of gene
expression, cell cycle, genome stability, and nuclear architecture. Over the past decade, a …

Histone modifications are thought to regulate chromatin structure, transcription and other
nuclear processes. Histone methylation was originally believed to be an irreversible …

F-box proteins, which are the substrate-recognition subunits of SKP1–cullin 1–F-box protein
(SCF) E3 ligase complexes, have pivotal roles in multiple cellular processes through …

In response to DNA damage, cells initiate complex signalling cascades leading to growth
arrest and DNA repair. The recruitment of 53BP1 to damaged sites requires the activation of …

Histone methylation plays fundamental roles in regulating chromatin‐based processes. With
the discovery of histone demethylases over a decade ago, it is now clear that histone …

Histone lysine demethylases (KDMs) are enzymes that remove the methylation marks on
lysines in nucleosomes' histone tails. These changes in methylation marks regulate gene …

Acquired chromosomal instability and copy number alterations are hallmarks of cancer.
Enzymes capable of promoting site-specific copy number changes have yet to be identified …

As the only surviving lineages of jawless fishes, hagfishes and lampreys provide a crucial
window into early vertebrate evolution,–. Here we investigate the complex history, timing …

KDM4 histone demethylases catalyze the removal of methyl marks from histone lysine
residues to epigenetically regulate chromatin structure and gene expression. KDM4 …