Methotrexate is used in the treatment of many malignancies, rheumatological diseases, and
inflammatory bowel disease. Toxicity from use is associated with severe morbidity and …

Methotrexate (MTX) toxicity varies depending on factors such as dosing frequency (acute or
repeated), dosage (low or high) and the administration route (oral, parenteral or intrathecal) …

Late infantile neuronal ceroid lipofuscinosis (LINCL) is a progressive neurodegenerative
lysosomal storage disorder caused by mutations in TPP1, the gene encoding the lysosomal …

Background: The central nervous system is a unique sanctuary site for malignant disease.
To ensure optimal disease control, intrathecal (IT) chemotherapy is commonly given in …

Although initial central nervous system (CNS) involvement is rarely detected in childhood
acute lymphoblastic leukemia (ALL), risk-adapted CNS-directed therapy is essential for all …

Background: Two 14-year old boys with acute lymphocytic leukemia were treated according
to the NOPHO-ALL-08 protocol with intrathecal methotrexate (MTX) on the same day. Due to …

Intrathecal chemotherapy is routinely prescribed in medical oncology practice, either for
prophylaxis or for treatment of leptomeningeal disease due to a primary haematological …

Errors involving patients receiving intrathecal chemotherapy are a significant problem in
oncology. Despite the improvement in the management of antineoplastic agents …

Intrathecal therapy with cytarabine is widely used in the treatment of acute lymphocytic
leukemia. We report the first case of accidental intrathecal cytarabine overdose in an adult …

Chemotherapy is an important intervention for the treatment of central nervous system (CNS)
malignancies, but the systemic approach is often suboptimal. The blood-brain barrier (BBB) …