Simple Summary Melanoma is a devastating skin cancer characterized by an impressive
metabolic plasticity. Melanoma cells are able to adapt to the tumor microenvironment by …

Cancer cells undergo drastic metabolic adaptions to cover increased bioenergetic needs,
contributing to resistance to therapies. This includes a higher demand for cholesterol, which …

Lipophilic weak base therapeutic agents, termed lysosomotropic drugs (LDs), undergo
marked sequestration and concentration within lysosomes, hence altering lysosomal …

Cancer represents a severe challenge to healthcare systems and individuals worldwide.
The development of multiple drug resistance is a major issue regarding cancer therapy …

A hallmark of the adaptive immune system is the specificity of B cell and T cell responses.
Mechanistically, this feature relies on the fact that the two genes that encode B cell and T cell …

CXCR7 and CXCR4 are G protein-coupled receptors (GPCRs) that can be stimulated by
CXCL12 in various human cancers. CXCR7/4–CXCL12 binding can initiate activation of …

Immunotherapy has revolutionized cancer treatment. Unfortunately, most tumor types do not
respond to immunotherapy due to a lack of immune infiltration or “cold” tumor …

The one-carbon homologation of carboxylic acids is a valuable route to construct families of
homologues, which play fundamental roles in chemistry and biology. However, known …

Simple Summary Autophagy is a cellular mechanism that is essential for removing misfolded
proteins and damaged organelles. Moreover, the aberrant activation of signal transducer …

Cancer is a major cause of morbidity and mortality worldwide. Chemotherapeutic agents
currently used in cancer treatment are associated with severe side effects and development …