Chromosome segregation during cell division requires a bipolar mitotic spindle. Therefore,
how the spindle is formed, maintained, and functions is of fundamental importance for all …

The kinesin class of microtubule-associated motor proteins present attractive anticancer
targets owing to their roles in key functions in dividing cells. Two interpolar mitotic kinesins …

Several kinesin-5 motors (kinesin-5s) exhibit bidirectional motility. The mechanism of such
motility remains unknown. Bidirectional kinesin-5s share a long N-terminal nonmotor …

Mitotic cell division is the most fundamental task of all living cells. Cells have intricate and
tightly regulated machinery to ensure that mitosis occurs with appropriate frequency and …

Kinesin motor proteins comprise an ATPase superfamily that works hand in hand with
microtubules in every eukaryote. The mitotic kinesins, by virtue of their potential therapeutic …

Kinesin-5 is required for forming the bipolar spindle during mitosis. Its motor domain, which
contains nucleotide and microtubule binding sites and mechanical elements to generate …

Kinesins are responsible for a wide variety of microtubule-based, ATP-dependent functions.
Their motor domain drives these activities, but the molecular adaptations that specify these …

Mitosis mediates the accurate separation of daughter cells, and abnormalities are closely
related to cancer progression. KIF11, a member of the kinesin family, plays a vital role in the …

The discovery of novel chemotherapeutic agents is always challenging for researchers in
industry and academia. Among the recent promising anticancer therapeutic targets, an …

Plasmodium parasites cause malaria and are responsible annually for hundreds of
thousands of deaths. Kinesins are a superfamily of microtubule-dependent ATPases that …