The extracellular matrix is perturbed in tumors. The tumor matrix promotes the growth,
survival, and invasion of the cancer and modifies fibroblast and immune cell behavior to …

Salivary glands produce and secrete saliva, which is essential for maintaining oral health
and overall health. Understanding both the unique structure and physiological function of …

Cell cultures are important material of study for the variety of advantages that they offer. Both
established continuous cell lines and primary cell cultures continue to be invaluable for …

In epithelial cancers, cells must invade through basement membranes (BMs) to metastasize.
The BM, a thin layer of extracellular matrix underlying epithelial and endothelial tissues, is …

Mammalian organs are challenging to study as they are fairly inaccessible to experimental
manipulation and optical observation. Recent advances in three-dimensional (3D) culture …

The extracellular matrix (ECM) is increasingly recognized as an important regulator in breast
cancer. ECM in breast cancer development features numerous changes in composition and …

The development of the mammary gland is unique: the final stages of development occur
postnatally at puberty under the influence of hormonal cues. Furthermore, during the life of …

The extracellular matrix (ECM) is the noncellular component present within all tissues and
organs, and provides not only essential physical scaffolding for the cellular constituents but …

Tumors are like new organs and are made of multiple cell types and components. The tumor
competes with the normal microenvironment to overcome antitumorigenic pressures. Before …

Solid tumors are not simply clones of cancer cells. Instead, they are abnormal organs
composed of multiple cell types and extracellular matrix. Some aspects of tumor …