Aminoglycoside (AG) antibiotics are used to treat many Gram-negative and some Gram-
positive infections and, importantly, multidrug-resistant tuberculosis. Among various …

Aminoglycosides are a group of antibiotics used since the 1940s to primarily treat a broad
spectrum of bacterial infections. The primary resistance mechanism against these antibiotics …

The emergence of new fungal pathogens makes the development of new antifungal drugs a
medical imperative that in recent years motivates the talents of numerous investigators …

The rise and emergence of resistance to antifungal drugs by diverse pathogenic fungal
strains have resulted in an increase in demand for new antifungal agents. Various …

BACKGROUND The literature shows that bisthioether and 1, 3, 4‐oxadiazole derivatives
exhibit a wide variety of biological activities. In this study, a series of novel bisthioether …

The extensive use of fluconazole (FLC) and other azole drugs has caused the emergence
and rise of azole-resistant fungi. The fungistatic nature of FLC in combination with toxicity …

Fungal pathogens cause over 6.5 million life-threatening systemic infections annually, with
mortality rates ranging from 20 to 95%, even with medical intervention. The World Health …

Chromosomally encoded low membrane permeability and highly efficient efflux systems are
major mechanisms by which Pseudomonas aeruginosa evades antibiotic actions. Our …

Azoles are antifungal drugs used to treat fungal infections such as candidiasis in humans.
Their extensive use has led to the emergence of drug resistance, complicating antifungal …

Fungal infections cause severe and life-threatening complications especially in
immunocompromised individuals. Antifungals targeting cellular machinery and cell …