Mesenchymal stem/stromal cell-based therapy: mechanism, systemic safety and biodistribution for precision clinical applications

WZ Zhuang, YH Lin, LJ Su, MS Wu, HY Jeng… - Journal of biomedical …, 2021 - Springer
Mesenchymal stem/stromal cells (MSCs) are a promising resource for cell-based therapy
because of their high immunomodulation ability, tropism towards inflamed and injured …

Mesenchymal stem cells: mechanisms of inflammation

NG Singer, AI Caplan - Annual Review of Pathology …, 2011 - annualreviews.org
In adults, human mesenchymal stem cells (hMSCs) are found in vivo at low frequency and
are defined by their capacity to differentiate into bone, cartilage, and adipose tissue …

Adipose tissue-derived multipotent stromal cells have a higher immunomodulatory capacity than their bone marrow-derived counterparts

SM Melief, JJ Zwaginga, WE Fibbe… - Stem cells translational …, 2013 - academic.oup.com
Adipose tissue-derived multipotent stromal cells (AT-MSCs) are studied as an alternative to
bone marrow-derived multipotent stromal cells (BM-MSCs) for immunomodulatory treatment …

Multipotent stromal cells induce human regulatory T cells through a novel pathway involving skewing of monocytes toward anti-inflammatory macrophages

SM Melief, E Schrama, MH Brugman… - Stem …, 2013 - academic.oup.com
Multipotent stromal cells (MSC) have been shown to possess immunomodulatory capacities
and are therefore explored as a novel cellular therapy. One of the mechanisms through …

Immunomodulatory functions of mesenchymal stem cells in tissue engineering

H Li, S Shen, H Fu, Z Wang, X Li, X Sui… - Stem cells …, 2019 - Wiley Online Library
The inflammatory response to chronic injury affects tissue regeneration and has become an
important factor influencing the prognosis of patients. In previous stem cell treatments, it was …

Immunomodulatory properties and therapeutic application of mesenchymal stem cells

M Shi, ZW Liu, FS Wang - Clinical & Experimental Immunology, 2011 - academic.oup.com
Mesenchymal stem cells (MSCs) are multi-potent progenitor cells that are isolated from the
bone marrow and several adult organs and tissues. These cells possess remarkable …

Immunological aspects of allogeneic mesenchymal stem cell therapies

MD Griffin, T Ritter, BP Mahon - Human gene therapy, 2010 - liebertpub.com
Allogeneic mesenchymal stem or stromal cells (MSCs) are proposed as cell therapies for
degenerative, inflammatory, and autoimmune diseases. The feasibility of allogeneic MSC …

The immunomodulatory properties of mesenchymal stem cells and their use for immunotherapy

MJ Hoogduijn, F Popp, R Verbeek, M Masoodi… - International …, 2010 - Elsevier
There is growing interest in the use of mesenchymal stem cells (MSC) for immune therapy.
Clinical trials that use MSC for treatment of therapy resistant graft versus host disease …

Allogeneic and xenogeneic transplantation of adipose-derived stem cells in immunocompetent recipients without immunosuppressants

CS Lin, G Lin, TF Lue - Stem cells and development, 2012 - liebertpub.com
Mesenchymal stem cells (MSCs) are well known for their immunomodulatory capabilities. In
particular, their immunosuppressive property is believed to permit their allogeneic or even …

Interactions between MSCs and immune cells: implications for bone healing

TK Kovach, AS Dighe, PI Lobo… - Journal of immunology …, 2015 - Wiley Online Library
It is estimated that, of the 7.9 million fractures sustained in the United States each year, 5%
to 20% result in delayed or impaired healing requiring therapeutic intervention. Following …